ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2377-3634/1410038

Diabetes and Dementia

Mario Barbagallo and Ligia J. Dominguez

Article Type: Commentary | First Published: August 03, 2015

Persons with type 2 diabetes mellitus (DM2) have an increased incidence of cognitive decline and dementia. An increased cortical and subcortical atrophy has been found after controlling for vascular disease and inadequate cerebral circulation. A possible role of insulin resistance and hyperinsulinemia has been suggested to mediate the link between DM2 and Alzheimer's Disease (AD). Altered insulin ...

 Open Access DOI:10.23937/2572-4215.1510001

Gross Motor Function Improvement in Children with Cerebral Palsy: A Case Series of Single-Event Multi-Level Chemoneurolysis Using Botulinum Toxin-A and/or Phenol Injections

Teerada Ploypetch, Jeong-Yi Kwon, Hilary F. Armstrong, Amanda C. Ayala and Heakyung Kim

Article Type: Research Article | First Published: July 17, 2015

Toxin injection has been a common option to manage spasticity in children with cerebral palsy (CP). Multi-level injections are recommended based on the fact that most patients have diffuse spasticity rather than focal spasticity. In order to achieve optimal limb alignment, a number of muscle groups are targeted. Bakheit et al. reported that multi-level Botulinum toxin-A (BTX-A) injections resulted...

 Open Access DOI:10.23937/2377-3634/1410037

Follow the Yellow Brick Road: The Pathway for NAFLD and NASH Drug Development in Early Phase Clinical Trials

Sabina Paglialunga and Clayton A. Dehn

Article Type: Commentary | First Published: July 31, 2015

The current market for type 2 diabetes mellitus (T2DM) medications is saturated with a plethora of choices of therapeutic agents, many of which have very favorable safety profiles. It has been proposed that the combination of this crowded and competitive landscape along with the increased burden of thorough cardiovascular risk assessment required since 2008, have stifled innovation in the developm...

 Open Access DOI:10.23937/2377-3634/1410036

Toxic AGEs (TAGE) Theory in the Pathogenesis of NAFLD and ALD

Masayoshi Takeuchi, Akiko Sakasai-Sakai, Jun-ichi Takino, Takanobu Takata, Tadashi Ueda and Mikihiro Tsutsumi

Article Type: Mini Review | First Published: July 31, 2015

Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) have become serious health problems worldwide. These two diseases have similar pathological spectra, ranging from simple hepatic steatosis to steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. NAFLD and ALD are frequently accompanied by extrahepatic complications, including cardiovascular disease and malignancy...

 Open Access DOI:10.23937/2572-4045.1510007

Impact of Donor Cytomegalovirus Serology and duration of Prophylaxis on Follow-Up Strategy in Lung Transplant Recipients

Jose M. Borro, Maria Delgado, Teresa Rey and Pablo Rama

Article Type: Original Article | First Published: July 04, 2015

Cytomegalovirus (CMV) infection is the most prevalent opportunistic infection after lung transplantation. It is reported in between 20% and 50% of cases after discontinuation of prophylaxis, depending on the series. CMV usually remains dormant in the lymphatic system, and its reactivation, due to immunosuppressive therapy, may have considerable adverse consequences in the immunocompromised host. I...

 Open Access DOI:10.23937/2378-3419/2/3/1019

Screening for the Polyomaviruses BKV, JCV and SV40 in Pediatric Malignancies

Karin Kosulin, Alexander Zimmerhack, Johannes A. Hainfellner, Christine Haberler, Gabriele Amann, Susanna Lang and Thomas Lion

Article Type: Research Article | First Published: July 31, 2015

Different studies suggested an oncogenic potential of the polyomaviruses JC virus, BK virus and simian virus 40, particularly in brain tumors and neuroblastoma, which belong to the most frequent malignancies in children. However, currently available data are controversial, possibly due to the different regional prevalence of the viruses and the detection techniques used. To elucidate the presence ...

 Open Access DOI:10.23937/2474-3674/1510002

Use of Dexmedetomidine in the Management of Alcohol Withdrawal Syndrome in Critically Ill Patients

Julie Kalabalik and Jesse B. Sullivan

Article Type: Review Article | First Published: July 30, 2015

Alcohol consumption plays a role in the development of over 200 diseases and conditions in individuals worldwide, including liver cirrhosis, cancers, traumatic injury, and alcohol dependence. In hospitalized patients with alcohol use disorders (AUD), up to 25% will develop acute alcohol withdrawal syndrome (AWS). In critically ill patients, presence of AWS is associated with increased duration of ...

 Open Access DOI:10.23937/2378-3648/1410016

Understanding the Host Epigenetics in Mycobacterium tuberculosis Infection

Vinod Yadav, Ved Prakash Dwivedi, Debapriya Bhattacharya, Ashwan

Article Type: Research Article | First Published: June 27, 2015

It was in 1942 when C.H. Waddington first coined the term epigenetics. According to him there is no direct relationship between a gene and its phenotype. He considered epigenetics as a part of development biology and in his opinion many times genotype and phenotype variations are not associated and phenotype differences do not necessarily involve change in genotype. Since 40s epigenetics became th...

 Open Access DOI:10.23937/2474-3631/1510006

Alcohol Withdrawal Syndrome: The Importance of Glutamatergic System

Jose Carlos F. Galduroz, Pedro Luis Prior and Anna Carolina Ramos

Article Type: Editorial | First Published: July 30, 2015

Alcohol withdrawal syndrome (AWS) is a complex phenomenon that involves several neurotransmission systems. Its signs and symptoms are related to the adrenergic autonomic hyperstimulation and to the hypofunction of the gabaergic system. Moreover, alcohol is an antagonist of the NMDA (N-Methyl-D-Aspartate) receptors, which are excitatory, in the central nervous system....

 Open Access DOI:10.23937/2469-5807/1510005

Flow Cytometric Analysis of Cell Size in B-Cell Non-Hodgkin Lymphoma: Reliability and Potential Diagnostic Significance

Aaron Cotrell, Farzaneh Sayedian, Michelle Huang, Xia Chen, Ming Xie, Marc Smith and James Huang

Article Type: Research Article | First Published: July 13, 2015

Evaluation of lymphoma cell size is a key step in the sub classification of B-cell lymphomas. Lymphoma cells can be classified as large, small or (less commonly) medium; but recognition of large B-cells is of particular importance because of their diagnostic and prognostic significance. Lymphomas with increased large cells are often associated with more aggressive clinical course. For instance, ne...

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Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target..
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Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?..
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Differences in ME and CFS Symptomology in Patients with Normal and..
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Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive..
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A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1..
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Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced..
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Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate..
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Electron Microscopic Analysis of Silicate and Calcium Particles..
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Effects of chest physical therapy in patients with non-tuberculous mycobacteria
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A Community-Based Exercise and Support Group Program Improves Quality..
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Social Ecology and Diabetes Self-Management among Pacific Islanders..
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Examining Characteristics of Hospitalizations in Heart Failure Patients: Results..
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