Study on the Variations of Image Density Index of MDCT for Healthy Lungs
Won-Bin Cha, Sok-Chan Yun, Chan-Ung Ri and Chol-Ho Chang
Article Type: Original Article | First Published: October 21, 2019
We selected several image density indices to establish CAD for prediction of biopsy in lung diseases. Our results suggested that significant difference was not observed in the image density indices between bilateral lungs at each slice level. Our own designed image indices may be reliable parameters in the establishment of CAD system and pathologic diagnosis for lung disease. There has been a rapid progress in the modality of CT since it was developed by Mr. Hounsfield. The earlier CT had been upgraded to the helical CT and for the time being the MDCT is widely used in the radiology practice. ...
Disseminated Cryptococcosis in a Deceptively Immunocompetent Adolescent
Vivek Sood, Raja Ramachandran, Rakesh Kumar Pilania, Arun Prabhakar, Neeraj Inamdar, Navin Pattanashetti, Vibhu Joshi, Madhubala Sharma, Amit Rawat, HS Kohli and KL Gupta
Article Type: Case Report | First Published: October 28, 2019
Cryptococcosis particularly if disseminated or extrapulmonary, in an otherwise immune-competent individual, especially if young, requires thorough evaluation for underlying primary immunodeficiency including Mendelian susceptibility to mycobacterial disease (MSMD). In this context, we describe an adolescent diagnosed with disseminated cryptococcosis involving skin, lymph nodes, spleen and hepato-biliary involvement with reduced IL-12β1 receptor expression suggesting underlying MSMD. Following initial management with conventional amphotericin and flucytosine, along with antibiotics for cholang...
Quality of Prevention of Mother-To-Child Transmission of HIV Service at South Wollo Zone Governmental Hospitals, Amhara Region, Ethiopia, 2018
Debrnesh Goshiye, Girum Sebsebie and Sisay Gedamu
Article Type: Research Article | First Published: October 16, 2019
Prevention of Mother-to-Child Transmission service is expanded out in accelerated fashion throughout Ethiopia with all public hospitals and health centers. However, published studies on the services' provision in the country are generally limited. If at all, they did not comprehensively examine quality of the services. The aim of the study was to assess the quality of Prevention of Mother-to-Child Transmission service at governmental Hospitals of South Wollo Zone, Amhara Region, Ethiopia, 2018. Convergent parallel mixed study was conducted at governmental hospitals of South Wollo Zone. A total...
Widespread Multi-Organ Involvement by Lymphoplasmacytic B-Cell Lymphoma in a Patient with Multiple Comorbidities: A Case Report
Oluwaseyi Olayinka, Gagandeep Kaur, Nusrat Pathan and Paul Fiedler
Article Type: Case Report | First Published: October 31, 2019
Lymphoplasmacytic lymphoma (LPL) is an uncommon B-cell non-Hodgkin lymphoma in which the affected tissue, usually bone marrow, is infiltrated by small lymphocytes, plasmacytoid lymphocytes, and plasma cells. The lymph nodes, spleen and other tissues/organs in the body are less commonly infiltrated by the neoplastic cells. The clinical course of LPL is indolent although some studies report a more aggressive course and adverse outcomes especially in patients with other primary malignancies including skin cancers. We report an unusual finding of widespread multi-organ involvement by LPL in a 69-y...
Transfer Factors or Dialyzable leukocyte Extracts as Immunomodulating Peptides: A Conceptual Review on Broad Spectrum of Therapeutic Areas, Immunologic and Clinical Responses, Trends and Perspectives
Dina Tulina, Mike KS Chan, Michele WBF and Shing Yi Pan
Article Type: Research Article | First Published: November 04, 2019
Immune Modulating Peptides (IMP) discussed in literature as a universal immunocorrectors with wide areas of usage which balance the immune system without causing global immune suppression or overreaction. The present article aim is to review the effect and drawbacks of IMPs in form of Dialyzable leukocyte Extracts (DLE) or Transfer Factors (TF) during and following chemotherapy, radiotherapy, drugs interactions, cancer response and clinical outcomes in different cases of cancers such as metastatic breast cancer, glioma, prostate cancer, osteosarcoma and others. The considered cases of immune o...
Review of the Effect of Religion on Anxiety
William C Stewart, MD, Megan J Wetselaar, BA, Lindsay A Nelson, BS and Jeanette A Stewart, RN
Article Type: Review Article | First Published: November 04, 2019
Very little information is available about the influence of religion upon anxiety. The objective of this article is to review the medical literature regarding the influence of personal religious belief and religious-based activities on anxiety. Studies were reviewed evaluating anxiety and the effect of religion in peer reviewed medical literature by using search terms in PubMed and Cochrane data bases. There were 32 studies included. This review showed, in almost every study, that religion in general, religious training, spirituality, faith, prayer, religious community and worship were associa...
Spontaneous Regression of Hepatic Diffuse Large B-cell Lymphoma in HIV and HCV Positive Patient: A Novel Case Study
Albert Alhatem, Saiaditya Badeti, Chen Liu, Dongfang Liu and Donghong Cai
Article Type: Case Report | First Published: October 23, 2019
Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/cytogenetics studies. He started HCV and HIV medication but refused lymphoma chemotherapy. Radiologic...
Optic Perineuritis Secondary to Sjogreen’s Syndrome: Case Report
Juliana Emy Tolachinski Oikawa, Julia Gomes Leite de Souza, Vitoria Caroline Cardoso Ferreira, Paulo Roberto Wille, MD, PhD, Laura Fiuza Parolin, MD and Marcus Vinícius Magno Goncalves, MD, PhD
Article Type: Case Report | First Published: November 04, 2019
Optic perineuritis (OPN) is a rare inflammatory disease involving the optic nerve sheath, causing pain and disc edema and is often bilateral. The diagnosis of OPN is commonly based on magnetic resonance imaging (MRI) findings and clinical features. In MRI it is possible to visualize a circumferential enhancement around the intraorbital optic nerve with preservation of the nerve itself (doughnut sign). This is better seen in contrast-enhanced and suppressed coronal MRI sequences with fat. Magnetic resonance imaging may also show enhancement of orbital fat and slight increase in extraocular musc...
Levo-Bupivacaine vs. Ropivacaine for Post-Operative Pain Relief after Pre-Emptive Intraperitoneal Instillation in Laparoscopic Appendicectomy
Thiruselvi Subramaniam and Tan Ann Jee
Article Type: Original Article | First Published: October 26, 2019
Pain in the immediate postoperative period is found to be less after laparoscopic than after conventional surgical techniques. Ropivacaine is often in favour of Bupivacaine to avoid the risks of toxicity. Levo-bupivacaine, a safer version of bupivacaine is a contender to Ropivacaine. We compare the pain relief provided by Ropivacaine and Levo-bupivacaine instilled intra-abdominally during laparoscopic surgery for acute appendicitis. This is a double blinded randomized placebo- controlled study conducted on 120 patients in a public hospital over a period of 10 months. Using patient control anal...
Skull Metastasis in Prostate Cancer: A Compilation of Four Cases along with Review of the Literature
Brahima KIRAKOYA Fasnewinde Aristide KABORE, Babagana Mustapha ABUBAKAR, Mohamed SIMPORE, Bienvenue Desire KY and Aïssata OUEDRAOGO
Article Type: Research Article | First Published: November 06, 2019
Skull metastasis in prostate cancer is rare and is seen in advanced cases. We study four cases seen in our facility with the aim of identifying challenges in making diagnosis and treatment of these patients. We also reviewed the literature. This study involved four men age 55, 65, 66 and 69 years. In two cases, the skull metastases were discovered during evaluation for primary skull swelling, no lower urinary tract symptoms (LUTS) at presentation. In the other two cases, skull metastases were discovered when the patients were evaluated for metastases after the diagnosed prostate cancer. There ...