New Treatment Strategies for Influenza
Luis del Carpio-Orantes
Article Type: Mini Review | First Published: January 28, 2015
After the pandemic influenza H1N1 2009, there are many lessons learned regarding the diagnosis and treatment of patients affected by this virus. However, there have also been a number of contingencies that have greater concern to the world population, mainly by new types as infectious outbreaks, as well as the report of virus mutations that confer resistance to common treatment widely used. For new outbreaks have resulted in a new calamity, after the A (H1N1) pdm09, mainly mentioned the influenza A H3N2, H5N1, and more recently isolated, from avian influenza H7N9 in China, identifying in each ...
An Enlarging Airway Foreign Body
Vijay Hadda, Kavitha Venkatnarayan, Karan Madan, Anant Mohan and GC Khilnani
Article Type: Case Report | First Published: January 26, 2015
A 25-year-old female patient presented with dry coughs of 20 days duration and fever for four days. Examination of respiratory system revealed no significant abnormality. Chest radiograph was normal. CT scan of the thorax revealed endobronchial opacity in the right main bronchus suggestive of a foreign body. Patient retrospectively recollected history of betel nut aspiration just prior to onset of symptoms. Flexible bronchoscopy revealed a large sized blackish-brownish large foreign (betel nut) in the right main bronchus which was successfully removed using the flexible bronchoscope itself. Du...
Recurrent Ischemic Strokes and Headaches Originating from Lambl's Excrescences: A Case-Report
Oana Dumitrascu and Evgeny Tsimerinov
Article Type: Case Report | First Published: January 31, 2015
Determining recurrent stroke etiology and subsequent therapeutic approaches is an important, but not always straightforward task. Lambl's Excrescences (LE) are cardiac valve strands that can be a source of recurrent cerebral ischemic events. We report the case of a 60 year old female that was seen in neurologic consultation for recurrent ischemic strokes. The patient developed migraine headache with complex auras at the age of 59. She reported three admissions for ischemic strokes in the past year. Stroke work-ups were unrevealing. The patient remained on daily Aspirin. Upon current admission,...
Macular Hole Formation Following Choroidal Neovascularization Treatment in A High Myopic Eye with Epiretinal Membrane
Yusaku Yoshida, Manabu Yamamoto, Takeya Kohno and Kunihiko Shiraki
Article Type: Case Report | First Published: January 21, 2015
Purpose: To report on the development of macular hole after treatment of choroidal neovascularization (CNV) in a patient with high myopia and epiretinal membrane (ERM). Methods: Retrospective single case report.Patients: A 60-year-old man presented with reduced vision in his right eye. On the initial examination, the right eye was high myopic with decimal best-corrected visual acuity (BCVA) of 0.3. Results: A subretinal grayish-white lesion was seen at the macula with hemorrhage, and optical coherence tomography showed a poorly demarcated, solid subretinal lesion and ERM in the central fovea. ...
Endoscopic Conservative Treatment for an Ureterovaginal Fistula Caused by Foreign Body
DeLeon E, Lankford D, Allman D, Phillibert D, Paolucci M, Gore S and Clare C
Article Type: Case Report | First Published: January 20, 2015
Foreign body placement in the vagina is a rare cause of ureterovaginal fistula. A fistula is often due to an unrecognized injury to the ureter, most commonly after gynecologic pelvic surgery, such as during hysterectomy for benign indications. This manuscript will discuss a case of a 34-year-old African American female who presents with a history of sexual assault and a one month history of urinary incontinence. Physical examination revealed clear liquid in the vaginal vault and a malodorous foreign body embedded in the vaginal mucosa. Cystoscopy ultimately confirmed a left ureterovaginal fist...
Cardiovascular Risk Factors, Diet and Lifestyle among a Group of Italian Young Adults Students
Gregoriana Zanini, Elio Gorga, Francesca Del Magro, Bola Okunuga, Federica Pasini and Gian Franco Pasini
Article Type: Research Article | First Published: January 06, 2015
The prevalence of cardiovascular disease has shown a marked increase over the last decade, representing the leading cause of death in the United States of America but also in Italy. Cardiovascular diseases recognize a multifactorial etiology: age, obesity, distribution of body fat, cigarette smoking, sedentary lifestyle, high blood pressure, dyslipidemia. In recent years has been paid particular attention to the cardiovascular risk factors prevention particularly in adulthood (> 30 years old). The aim of our study was to evaluate the lifestyle in young subjects (20 years old) particularly in a...
Does the Benefit of Therapeutic Hypothermia in Refractory Status Epilepticus Depend on Seizure Etiology?
Jessica R. Fesler, Ryan Hakimi, Emmaculate M. Fields and Andrea S. Hakimi
Article Type: Original Article | First Published: January 19, 2015
Introduction : Refractory status epilepticus (RSE) is seizure activity that persists despite acute administration of standard anticonvulsant therapy. It often occurs after cardiac arrest, indicating a poor prognosis. Therapeutic hypothermia (TH) reduces neurological injury in this patient population, and post cardiac arrest protocols now incorporate TH into the treatment algorithm. However, TH is not routinely used in RSE from other etiologies and little is known about the appropriate role of TH as an adjunct therapy. Methods: Five consecutive patients with RSE admitted to our neurocritical ca...
Primitive Fallopian Tube Carcinosarcoma: Three Cases with Immunohistochemical Profiling
Mira Akiki, Fereshteh Farkhondeh, Virginie Fourchotte and Xavier Sastre-Garau
Article Type: Case Report | First Published: January 22, 2015
Most carcinosarcoma, formerly designed as Malignant Mixed Mullerian Tumors are found in the uterus or the ovary, but rarely in the fallopian tube. The histogenesis of this type of tumor and its place regarding serous or poorly differentiated carcinoma are discussed. We document here three typical cases primarily developed in the fallopian tube. The patients were 69, 70 and 82 years old. They all presented with abdominal pain and large unilateral adnexal mass apparently confined to the ovary. Bilateral salpingo-oophorectomy was performed in all cases. Macroscopically, the tumors were located on...
Smac13-Tat Fusion Peptide Induces Cell Death and Sensitizes HeLa Cells to Chemotherapeutic Drugs
Yoshinori Mano, Toshihiko Torigoe, Hiroko Asanuma, Yoshihiko Hirohashi and Noriyuki Sato
Article Type: Original Article | First Published: January 19, 2015
Background: The inhibitor of apoptosis proteins (IAPs) are overexpressed in a variety of cancer cells and play an important role in the inhibition of caspases, thereby suppressing programed cell death and leading to chemoresistance of cancer cells. However, the anti-apoptotic function of IAPs could be suppressed by Smac, the second mitochondria-derived activator of caspase through its direct interaction with IAPs. Smac can interact with IAPs through the N-terminal Ala-Val-Pro-Ile tetrapeptide domain.
Methods: In the present study, the first 7 amino acid sequence (residues 54-60), Smac7,and t...