ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.



  Last Updated: October 27, 2020

ClinMed Archive

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2378-3516/1410009

Halotherapy in Patients with Cystic Fibrosis: A Pilot Study

Morhaf AlAchkar, David E. Geller, Amanshe Perera Slaney and Daniel T Layish

Article Type: Research Article | First Published: January 04, 2015

Objectives: Cystic fibrosis (CF) is a complex genetic disorder of the lower and upper respiratory tract. The purpose of this study is to evaluate the effect of Halotherapy on sinusitis symptoms, dyspnea, pulmonary function tests, and quality of life in CF patients. Study design: This was a pilot open-label before-and-after-study. Settings: The study was performed at the Orlando Salt Room. Participants were from a single CF care center, and were enrolled in the study between January and June, 201...

 Open Access DOI:10.23937/2378-3516/1410008

Continuous Abstinence Rates at 3, 6, 9 and 12 Months in a Smoking Cessation Unit at the Albacete University Hospital Over 2 Years

Callejas Gonzalez FJ, Genoves Crespo M, Cruz Ruiz J, Tornero Molina AI, Esquinas Lopez C, Bermejo Lopez P, Garcia Castillo S, Martinez Garcia AJ, Rodriguez Montes JA5 and Tarraga Lopez PJ

Article Type: Research Article | First Published: January 04, 2015

838 patients referred 559 attended to and only 278 treated (33%); 55.4% males and 44.6% females; mean age of 46.4 years. The most important comorbidities were psychiatric (36.3%), cardiovascular (dyslipidemia 30.2%, hypertension 19.1%, diabetes 9.4%) and respiratory (chronic obstructive pulmonary disease (COPD), 15.1%; Obstructive Sleep Apnea Syndrome (OSAS), 11.9%; asthma, 7.6%). Treatments included varenicline (VRN), 36.7%, nicotine replacement therapy (NRT), 43.4%, bupropion, 13.3%, and psych...

 Open Access DOI:10.23937/2378-3001/2/1/1017

Intravenous Infusion of Ginsenoside Rb1 Ameliorates Compressive Spinal Cord Injury through Upregulation of Bcl-xL and VEGF

Pengxiang Zhu, Ryuji Hata, Kimihiko Nakata, Fang Cao, Keiichi Samukawa, Hiroko Fujita and Masahiro Sakanaka

Article Type: Research Article | First Published: January 15, 2015

Red ginseng root (Panax Ginseng C.A. Meyer) has been used clinically by many Asian people for thousands of years without any detrimental effects. Subsequent studies that focused on gRb1-induced expression of gene products responsible for neuronal death or survival revealed that gRb1 upregulated the expression of not only Bcl-XL, but also a potent angiogenic and neurotrophic factor, vascular endothelial growth factor (VEGF) at 7 days after SCI. Ginsenoside Rb1 (gRb1), with putative anti-apoptoti...

 Open Access DOI:10.23937/2378-3001/2/1/1016

Cortical Diffusion Restriction as the Single Abnormality on MRI in Creutzfeldt-Jakob disease

Johnny Samijn, Alisha Godschalk, Rezan Demir and Esther Brusse

Article Type: Case Report | First Published: January 12, 2015

Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease characterized by rapidly progressive dementia, ataxia and myoclonus. MRI is an important tool in discriminating CJD from other dementias. Among mimics of CJD are rapidly evolving Alzheimer's disease, vascular dementia, frontotemporal dementia and paraneoplastic or immune-mediated limbic encephalitis. A CJD diagnosis can be missed and strong clinical suspicion is not always confirmed on autopsy. Typical imaging findings are white...

 Open Access DOI:10.23937/2378-3001/2/1/1015

Basis and Argument into the Work

Roberto Rodrigues, George Perry and Robert Petersen

Article Type: Review Article | First Published: January 12, 2015

This synopsis is a brief report about the conclusions in which we have engaged from considering that Alzheimer's disease, cognitive impairment and aging could progress with analogous molecular signaling, with no frontiers between their phenotypes. We have also proposed that chronic depression, with or no anxiety and/or stress comorbidindication may interact with these AD manifestations - already product of genomic vulnerability - at any stage of the disease. A known example may bemutant short al...

 Open Access DOI:10.23937/2378-3001/2/1/1014

Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized

Troy T. Rohn

Article Type: Hypothesis | First Published: January 12, 2015

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an array of symptoms affecting memory and cognition. Some common symptoms of AD include memory loss that disrupts daily life, challenges in planning or solving problems, confusion with time or place, and changes in mood and personality. Central dogma to the etiology of AD is the beta-amyloid cascade, which stipulates that beta-amyloid in oligomeric forms represents the earliest step in a cascade eventually lead...

 Open Access DOI:10.23937/2378-3672/1410003

Analyze the Levels of Immunoglobulins IgG and IgM in Elderly and Youngs

Samia Macedo Queiroz Mota Castellao Tavares, Wilame de Lima Bravo Junior and Jessica Lissandra Alves Leite

Article Type: Research Article | First Published: January 16, 2015

The aging process is complex and affects a variety of functions, including lower defense capability of the immune system. The immune activity, as most of physiological functions, decreases with age. The principal alterations in humoral immune response are associated with concentration of immunoglobulins, amount and activity of B cells and also the changes in the affinity of the antibodies. The current study aimed to analyze the levels of IgG and IgM antibodies of elderly and young people and to ...

 Open Access DOI:10.23937/2378-3656/1410014

Atrial Fibrillation Triggered by Theophylline: a Case Report Treated with 'Pill in the Pocket'

Ekrem Sahan and Suzan Sahan

Article Type: Case Report | First Published: January 04, 2015

Atrial fibrillation (AF) is the most common sustained arrhythmia and the prevalence of AF increases with age. Ageing, hypertension, coronary artery disease, heart failure, diabetes mellitus, valvular heart diseases, congenital heart defects, thyroid dysfunctions, chronic obstructive pulmonary disease, drugs and alcohol are associated with atrial fibrilliation. New-onset AF can be converted to sinus rhythm. 'Pill in the Pocket' administration can be effective in new-onset AF. Herein, we present a...

 Open Access DOI:10.23937/2377-3634/1410017

Effect of Alogliptin, a DPP-4 Inhibitor, on Markers of Lipid Metabolism in Type 2 Diabetic Patients

Yuzuru Kishitani, Hideyuki Okuda, Daisuke Kinoshita, Kanyun Hata and Toshihiko Kawasaki

Article Type: Research Article | First Published: December 31, 2014

Background: DPP-4 inhibitor has been shown to improve not only blood glucose levels but also dyslipidemia, but the effect remains controversial. Further, there are few reports regarding the influence on Apo B, Apo A-1 and Apo B/Apo A-1 in alogliptin. Objective: Using the alogliptin, we focused on Apo B and Apo A-1, in addition to LDL-C, HDL-C and TG, and investigated the effect of alogliptin on markers predicting cardiovascular events, such as Apo B/Apo A-1 and LDL-C/Apo B....

 Open Access DOI:10.23937/2377-3634/1410016

Correlations of OSA Severity and Carotid Intima-Media Thickness in Patients with Type 2 Diabetes

Jiang Xiao-zhen, Xi Feng, Chen Rui-Hua, Jiang Quan and Zou Yu-Feng

Article Type: Review Article | First Published: December 29, 2014

Aim: To determine whether carotid intima-media thickness (C-IMT) was elevated in diabetic patients with Obstructive Sleep Apnea (OSA), and correlations of OSA severity with IMT and other clinical characteristics. Materials and methods: The study subjects were composed of 36 diabetic patients with OSA (group A), and 34 patients without OSA (group B). In both groups, blood lipids, fasting blood glucose, glycated hemoglobin, Epworth Sleepiness Scale, C-IMT and carotid resistance index (C-RI) were a...

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