Defining a Growing and Maturing Skeleton and its Relevance in Diseases that Affect Skeletal Growth, Such as X-Linked Hypophosphataemia (XLH)
Signe Beck-Nielsen, Nella Augusta Greggio and Lars Hagenӓs
Article Type: Review Article | First Published: April 17, 2021
The human skeleton is composed of bone, a living tissue that undergoes constant development throughout life. It is well established that changes in bone metabolism during the developmental stages of growth, modelling and remodelling determine long-lasting physiological parameters, such as final height achieved, peak bone mass, bone quality and bone health. A complex interplay of environmental, genetic, nutritional, physiological and behavioural factors plays a role in these processes. These modi...
On the Impact of Premature Termination of Chemotherapy on Relapse of Breast Cancer
Heidrun Männle, Karsten Münstedt, Felix Momm and Jan Willem Siebers
Article Type: Original Article | First Published: March 15, 2021
Some breast cancer patients receive a recommendation for adjuvant chemotherapy if necessary. In some cases, patients refuse this recommendation. In other cases, they start with chemotherapy, but then discontinue it. The question raised here are the effects of patients’ rejection or premature termination of recommended chemotherapies. 1916 patients, who received a recommendation for chemotherapy, were analyzed between 1997 and 2017. The analyses included descriptive analyses and Kaplan- Meier s...
Implantations and Applications of Brain Computer Interfaces as Medical Devices: A Short Review of Engineering Ethics
Akram Jassim Jawad
Article Type: Short Review | First Published: March 28, 2021
Nowadays, smart home devices have started to take a part in everything in our life, which mainly have been developed to consist from brain computer interface (BCI). In recent months, Neuralink BCI (1024-Electode) has been approved to be used by Food and Drug Administration (FDA) in the USA. That makes the ethical related studies have more attention to apply these devices and technologies in our daily life with more security. In this work, the ethical challenges of smart home systems that use BCI...
Can Statins Be Beneficial in COVID 19 Patients?
Mouin Jammal, Moussa Riachy and Fady Haddad
Article Type: Letter to Editor | First Published: April 17, 2021
Covid-19 remains a novel pandemic with many controversies and variable clinical expression and severity. Diabetes and a pre-existing cardiovascular disease are the greatest risk factor for severe Covid-19. The overall case fatality rate of 2.3% in the general population increases to 7.3% in presence of diabetes and reaches 15% in presence of a pre-existing cardiovascular disease. Age, smoking, arterial hypertension, hypercholesterolemia, diabetes and obesity predict a severe Covid- 19. MyD88 gen...
Prognostic Significance of Hormone Receptor (ER/PR) Status Inendometrial Carcinoma in Black Women: Implications with Lymph Node Metastasis
Manan Shah, Gabriela Oprea, Saba Shafi, Phani Keerthi Surapaneni, Sandeep Sasidharan, and Sanjay Jain
Article Type: Original Research | First Published: April 19, 2021
Loss of estrogen and progesterone receptors (ER/ PR) independently predicts lymph node metastasis and poor prognosis. Black females in comparison to their white counterparts are diagnosed at a later stage, with higher grade, poorer prognostic histology, and worse outcomes. We reviewed black females (n = 70) diagnosed with endometrial cancer at our institution from 2015-2018 including endometroid/ non-endometroid histology, FIGO stage I-IVA, grade 1-3 for ER/PR receptors and presence or absence o...
HER2/Neu Distribution in Female Breast Cancer in Libya: Correlation with Clinicopathological Features and Survival
Abdalla O Jebriel, Jens Huober and Fathi B Abdalla
Article Type: Original Article | First Published: April 18, 2021
HER2 protein over-expression is of great importance to guide hormone therapy. The present study aimed to determine the HER2 status of Libyan women with breast cancer and evaluate the correlation of HER2 expression with some clinicopathological features as well as overall survival (OS). Data on 245 women with a diagnosis of breast cancer who were registered at the Misurata Cancer Center (MCC) in Libya from January 2004 to December 2012 were retrospectively studied. Patients’ demographic and cli...
Acute Occlusion of the Lower Limb Artery Associated with Hyperosmolar Hyperglycemic Nonketotic Coma in a Patient with Amyotrophic Lateral Sclerosis: A Case Report
Kyoko Hayashida, MD, PhD, Shinsuke Masuda, MD, Yuichiro Yuchi, MD, Tsutomu Matsushita, MD, PhD and Kazuki Morimoto, MD
Article Type: Case Report | First Published: April 17, 2021
A 61-year-old man with amyotrophic lateral sclerosis (ALS) on tracheostomy positive pressure ventilation was brought to the emergency room due to decreased consciousness. He was diagnosed with hyperosmolar hyperglycemic nonketotic coma (HHNC) with severe systemic hypotension. He exhibited an adequate response to treatment of continuous intravenous insulin infusion and fluid replacement. On the third day, he developed acute limb ischemia due to extensive occlusion from the left common iliac arter...
Evaluation of Obstetric Patient Transfers by Helicopter in Turkey
Asiye Uzun, MD, Eren Usul, MD, Gülşah Çıkrıkçı Işık, MD, Semih Korkut, MD
Article Type: Original Research | First Published: April 09, 2021
Air ambulance services, which began in 2008 in our country, have become increasingly widespread. Today, there are command centers in 17 cities, and helicopter ambulances are preferably provided during the day, while air craft ambulances are used at night. The aim of the present study was to examine the characteristics of obstetric patient transfers by helicopter ambulance throughout Turkey in 2020. This study was started after receiving permission from the Turkish Ministry of Health, and all obs...
Psychophysiological Differences in Patients with/without Schizophrenia: A Comparative Study
Theofilidis Antonis and Fountoulakis Konstantinos
Article Type: Original Article | First Published: April 09, 2021
Schizophrenia is a chronic and severe mental disorder affecting 20 million people worldwide. Characterized by distortions in thinking, perception, emotions, language, sense of self and behaviour. Differences in body mass index, weight and height, in patients with schizophrenia, mood disorders vs. normal controls. The study sample included 76 patients with unipolar depression, 16 patients with schizoaffective disorder, 122 patients with schizophrenia, and 78 patients with other mental disorders,...
Occupational Health Nursing: A Specialty under Debate
Article Type: Short Review | First Published: March 31, 2021
The exercise of occupational health nursing based on the acquisition of competencies allows them to fully carry out their tasks, acquire levels of autonomous decision, make their role visible as a collective and record their contribution in this very specific work scenario. Considering the active role it plays in the context of organizations, its contribution allows guaranteeing the well-being of the people who are the object of its care, the working population. The occupational health nursing s...