International Archives of Internal Medicine is an international, open access, peer reviewed journal focused to enhance the knowledge in the field of medicine covering a wide range of conditions affecting the internal organs of the body - the heart, the lungs, the liver and gastro-intestinal tract, the kidneys and urinary tract, the brain, spinal column, nerves, muscles and joints. Internists also deal with some diseases specifically affect individual organs, the majority of common diseases - arteriosclerosis, diabetes, high blood pressure and cancer may affect many internal organs of the body.
With respect to multidisciplinary approach in research, this journal fosters an environment for physicians, to publish their works on topics, acute medicine, cardiology, clinical genetics, clinical neurophysiology, clinical pharmacology and therapeutics, dermatology, endocrinology and diabetes mellitus, gastroenterology, general medicine, genito-urinary medicine, geriatric medicine, hematology, immunology, infectious diseases, medical oncology, ophthalmology, neurology, nuclear medicine, pediatric cardiology, palliative medicine, pharmaceutical medicine, rehabilitation medicine, renal medicine, respiratory medicine, rheumatology, sport and exercise medicine, tropical medicine, etc.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2643-4466/1710039
Aziz Atallah, Ghofrane Talbi, Firas Ayadi, Fatma Medhioub, Ferjaoui Wael, Mestiri Hafedh and Rached Bayar
Article Type: Research Article | First Published: October 09, 2022
Liver resection for hepatocellular carcinoma in patients with normal or chronic liver disease remains a major therapeutic tool. Its indications keep expanding over the years nevertheless it is still burdened with a significant morbidity and mortality. The purpose of our study was to investigate the postoperative morbidity and mortality of the liver resection in patients with hepatocellular carcinoma on cirrhotic liver, chronic liver disease or normal liver and to identify its risk factors....
Open Access DOI:10.23937/2643-4466/1710038
Yalini Thivaharana and Indira Deepthi Gamage Kitulwatteb
Article Type: Review Article | First Published: June 30, 2022
Cerebral concussion is a minor and reversible functional abnormality and due its relatively minor nature it usually goes undetected and underreported. Despite increased knowledge and awareness of concussion and its long-term sequelae, effective measures of diagnosis, prognosis and treatment still appear to be deficient....
Open Access DOI:10.23937/2643-4466/1710037
Vasiliki Vanesa Stylianou, BSc, MD, Avgoustina Kyriakou, MD and Lorentzos Kapetis, MD, Msc
Article Type: Case Report | First Published: June 30, 2022
Hyponatremia is defined as serum concentration of sodium below 135 mEq/L. It is the most common electrolyte disturbance in daily clinical practice and is associated with high morbidity and mortality....
Open Access DOI:10.23937/2643-4466/1710036
Steven S Witkin, Daniel Skupski, Antonio F Moron, Allison Boester, Iara M Linhares and Larry J Forney
Article Type: Research Article | First Published: December 31, 2021
Bacteria from the vagina are transported into the uterus during labor. We evaluated if the vaginal microbiome in the third trimester of pregnancy was related to the length of the second stage of labor. The composition of the vaginal microbiome in 73 women in their third trimester was measured by analysis of the V1-V3 region of the gene coding for bacterial 16S ribosomal RNA. The vaginal concentration of D- and L-lactic acid was determined by ELISA. The time from full dilation to delivery was ob...
Open Access DOI:10.23937/2643-4466/1710035
Maiara A Floriani, MSc, Marina Bessel, ScD, Isabelle W Zorzo, BSHCA, Andressa B Glaeser, BSc, Rafael Domingos Grando, MD, Raphael Goveia Rodeghiero, MD, Mohamed Mutlaq Parrini, BEcon, MPhil, Gisele Nader Bastos, MD, ScD and Luiz Antonio Nasi, MD, ScD
Article Type: Research Article | First Published: December 31, 2021
We do not have detailed evidence on conditions or treatments that act as predictors of hospital outcomes. To identify the clinical predictors of hospital outcomes in COVID-19 patients and to evaluate the effect of therapeutic’s interventions on length of stay, ICU admission, need for mechanical ventilation (MV) and mortality. The primary outcome was to assess whether any treatment alone or in combination with standard care, was able to reduce ICU admission, need for MV or mortality. The second...
Open Access DOI:10.23937/2643-4466/1710034
Babić Žarko, MD, PhD, Vukelić Marković Mirjana, MD, PhD, Banić Marko, MD, PhD and Medić Barbara, MD
Article Type: Case Report | First Published: September 29, 2021
A number of complications are known to occur in the course of inflammatory bowel diseases. However, perianal fistulas and fissure can occur with or without active inflammatory bowel disease, occurrence of which prior to the development of ulcerative colitis is a rare occasion. Here we report a case of ulcerative colitis, which was misdiagnosed, treated as a perianal fissure and anal pressure ulcer without recognizing inflammatory bowel disease. Inflammmatory bowel diseases (IBDs) are chronic imm...
Open Access DOI:10.23937/2643-4466/1710033
Muhammad Zubair Khan, MD, Shaheer Zahid, MD, Sona Franklin, MD, Jamaluddin Saeed, MD, Vincent M Figueredo, MD, Steven Kutalek, MD and James Kilcoyne, DO
Article Type: Case Report | First Published: May 10, 2021
COVID-19 virus does not directly affect the heart. The virus can cause systematic inflammation that can lead to severe cardiac complications like uncontrolled atrial fibrillation (AF), which carries high mortality among patients. We present a case of an 82-year-old female from nursing home with advanced dementia and multiple comorbidities. She initially screened negative for COVID-19 in the nursing home, however her repeat test was positive. Soon after admission she developed progressive, hypoxi...
Open Access DOI:10.23937/2643-4466/1710032
Mayand Vakil, MD, Aron Kandinov, MD and Evelyne Kalyoussef, MD
Article Type: Case Report | First Published: April 03, 2021
Branchial cleft cysts are frequent causes of congenital neck masses-second only to thyroglossal duct cysts. Often asymptomatic, these masses can be missed until adulthood. The branchial apparatus is comprised of 3 parts: Arch, cleft, and pouch; these parts develop into the soft tissue, cartilaginous, and bony structures the mandible and neck. Incomplete obliteration is thought to result in branchial anomalies. First branchial cleft anomalies (FBCA) are quite rare, comprising less than 8% of all ...
Open Access DOI:10.23937/2643-4466/1710031
Yi Hua Wu, Wen Hsin Huang, Chi Ying Yang and Kai Po Chang
Article Type: Images | First Published: February 19, 2021
A 49-year-old man with a history of chronic hepatitis B presented to our outpatient clinic with occasional epigastric pain and intermittent fullness lasting 3 months. Duodenoscopy revealed ~1.5-cm broad-based polypoid ampullary mass with smooth and hyperemic mucosa (Figure 1A). Endoscopic ultrasonography (EUS) revealed an ampullary mass with hypoechoic and heterogeneous echogenicity involving mucosal and submucosal layers without an evidence of extension into either the biliary or pancreatic duc...
Open Access DOI:10.23937/2643-4466/1710030
Ghufran Jassim and Ahmed AlAnsari
Article Type: Research Article | First Published: October 19, 2020
A cross-sectional study was carried out on a total of 337 subjects recruited from the Oncology Centre in Bahrain. The European Organization for Research and Treatment-QOL questionnaire and breast cancer specific module (EORTC QLQ-C30 and QLQ-BR23) were used to measure the HRQOL among women with breast cancer. All statistical tests were performed using SPSS Version 20. The reliability of the EORTC QLQ-C30 and QLQ-BR23 questionnaires was examined using Cronbach’s alpha test. The construct validi...
Open Access DOI:10.23937/2643-4466/1710029
Mina A Gaballa, DO, Mohammed Z Shariff, MD and Mohammad A Hossain, MD
Article Type: Case Report | First Published: October 03, 2020
Malignant hyperthermia (MH) is a rare but potentially life threatening drug related reaction predisposed by genetic factors. Although most cases develop within the intraoperative setting, less commonly, delayed onset presentations have also been reported. With variability in symptoms and time of onset, definitive diagnosis of MH is challenging. Herein, we report a case of a 73-year-old man presented with severe oliguria in the setting of recent surgical procedure. He was found to have acute kidn...
Open Access DOI:10.23937/2643-4466/1710028
Maha Hossam Eldin Ibrahim and Abeer Awad Abdellatif
Article Type: Review Article | First Published: September 14, 2020
Nowadays, the entire world is facing the outbreak pandemic of COVID-19 infection which is a lethal infection to some extent. The most commonly affected group of population is the elderly due to impaired immunity and multiple co-morbidities they suffer from. From this point of view; we will discuss some important issues about the elderly involvement during COVID-19 pandemic hoping to raise the awareness toward that frail sector of population. Indeed many researches for COVID infection whether reg...
Open Access DOI:10.23937/2643-4466/1710027
Benjamin J Scherlag, PhD, Ronald A Scherlag, BS, MBA and Sunny S Po, MD, PhD
Article Type: Commentary | First Published: September 05, 2020
As the pandemic rages across the globe, we await the proven safe and effective vaccine that will turn the tide against the novel coronavirus SARS-CoV-2 (a.k.a. COVID-19) spread. In the meantime, a number of pharmaceutical agents have been the subject of studies including, Hydroxychloroquine, Remdesivir, Dexamethasone, among others with varying degrees of clinical efficacy. Hidden from the medical literature is the evidence gathered by investigators for more than a decade that negative air ions c...
Open Access DOI:10.23937/2643-4466/1710026
Kimiko Ueda, MD, MPH, PhD and Nobuhiko Okamoto, MD
Article Type: Research Article | First Published: May 02, 2020
In both cohorts, more than half of the subjects, regardless of gender, had dyslipidemia. Hyperuricemia and obesity were significantly more frequent in at-home-care men than in institutionalized men. The most common diseases in the institutionalized subjects were dyslipidemia (61%), ringworm (59.3%), hypothyroidism (30.5%), hyperuricemia (25.4%) and dementia (16.9%; 46% in those in their 60s). Subjects in their 50s or later showed a greater need for assistance in walking/moving, getting dressed a...
Open Access DOI:10.23937/2643-4466/1710025
Rama P Namuduri, Mihir Gudi and Soo Kim Lim Tan
Article Type: Case Report | First Published: May 02, 2020
Extraocular sebaceous carcinoma is an uncommon malignant tumor that usually affects the head and neck. Despite being rich in sebaceous glands, vulvar sebaceous carcinoma is extremely rare. We report a case of vulvar sebaceous carcinoma in a 64-year-old woman that presented as an asymptomatic nodule and was successfully treated by wide local excision. The number of reported cases of vulvar sebaceous carcinoma is very small, more cases need to be collected in order to identify prognostic factors a...
Open Access DOI:10.23937/2643-4466/1710024
Sheena Bhushan, Rebecca Richards-Kortum and Sharmila Anandasabapathy
Article Type: Review Article | First Published: April 23, 2020
In recent years, gastrointestinal endoscopy has seen an influx of high-resolution endoscopic technologies that are capable of providing optical biopsies of the epithelial surface in real time. Upcoming high-resolution endoscopy techniques are CLE, OCT, EC and HRME. Powered by automated diagnostic algorithms and more-cost effective alternatives, these high-resolution endoscopic technologies have the potential to not only facilitate real-time decision making, but also improve screening and surveil...
Open Access DOI:10.23937/2643-4466/1710022
Nuria Barrientos Perez, MD, Patricia Ibeas Millan, MD and Jose Domingo Dominguez Aunon, PhD
Article Type: Case Report | First Published: February 28, 2020
Serpentine supravenous dermatitis is a rare eruption related with cytotoxic drug infusion. Several chemotherapeutic agents have been related with this entity. But, most of the published cases are caused by docetaxel. However, considering the high frequency of administration in oncology this rather unknown eruption should be known to all physicians, especially oncologist, dermatologist, internist and GP....
Open Access DOI:10.23937/2643-4466/1710023
Arabella L Simpkin, MD, MMSc, Susan Hata, MD, Merranda Logan, MD, MPH and Katrina A Armstrong, MD, MSCE
Article Type: Research Article | First Published: March 28, 2020
Burnout is an accelerating phenomenon in the healthcare environment, with implications for physician wellbeing, patient safety, and the quality of healthcare. The ability to manage uncertainty has been identified as a potentially important determinant of burnout in physicians and is now a recognized competency for trainees. No prior studies have evaluated the association of fellows’ reaction to uncertainty with burnout metrics, including resilience and engagement. Cross-sectional online survey...
Open Access DOI:10.23937/2643-4466/1710021
Antonio Villa, MD
Article Type: Case Report | First Published: November 23, 2019
Peripheral neuropathies are well-known complications of primary systemic vasculitides. Antineutrophil cytoplasmic antibody (ANCA)-associated small vessel systemic vasculitides and medium-sized vessel vasculitis are known to frequently damage the peripheral nervous system. A 47-year-old man had a fifteen day history of pain in his lower and upper limbs associated to paresthesias and hypostenia. His medical history revealed no history of asthma, but in the last year some episodes of obstructive- c...
Open Access DOI:10.23937/2643-4466/1710020
Jun Park, MD and Vishal Sehgal, MD
Article Type: Case Report | First Published: September 26, 2019
Langerhans Cell Histiocytosis (LCH) is a rare disorder with an incident of 1.8 cases per 1,000,000. It involves granulomatous deposits in multiple organs, leading to a wide variety of manifestations such as bone lesions, pulmonary nodules, pituitary lesions, and skin lesions. With mucocutaneous manifestation, it is often diagnosed in childhood, typically making LCH a childhood disease. However, due to the involvement of multiple organ systems and variable clinical courses, if not diagnosed durin...
Open Access DOI:10.23937/2643-4466/1710019
Article Type: Research Article | First Published: September 21, 2019
Helicobacter pylori affects many individuals in developing countries. Inflammation caused by helicobacter pylori differs depending on the virulence factors, density and host tissue response of the bacteria. This study is intended to investigate the relation between density of helicobacter pylori colonization in gastric mucosa in biopsy specimens and gastric mucosal inflammation severity. Helicobacter pylori (H. pylori/Hp) is a microaerophilic gram negative bacilli initially detected in the antra...
Open Access DOI:10.23937/2643-4466/1710018
Madeeha Mian, BA, Annika S Silfvast-Kaiser, MD, So Yeon Paek, MD, Dario Kivelevitch, MD and Alan Menter, MD
Article Type: Review Article | First Published: July 22, 2019
The majority of skin conditions are not life-threatening; however, many can be severe and disfiguring enough to devastate a patient's quality of life. Skin diseases can significantly impact not only a patient's physical appearance, but also their social and emotional well-being. Even the smallest skin lesions have been shown to disrupt a person's level of overall wellness. Here, we aim to address the potential psychological and emotional impact of the most common and debilitating dermatologic co...
Open Access DOI:10.23937/2643-4466/1710017
Article Type: Research Article | First Published: July 19, 2019
Vitamin D deficiency may be the underlying cause of most health issues and diseases. There are few studies investigating the effect of low vitamin D levels on the cardiac arrhythmias. The electrocardiographic Tpeak to Tend (Tpe) interval and Tpe/QT ratio may associate with increased ventricular arrhythmias. The goal of this study was to evaluate the relationship between ventricular repolarization and vitamin D levels in apparently healthy individuals by using Tpe interval, Tpe/QT ratio and Tpe/c...
Open Access DOI:10.23937/2643-4466/1710016
Vitor S Mendonca and Maria Luisa S Schmidt
Article Type: Research Article | First Published: July 03, 2019
The study intended to analyze physician's post medical error disclosure process. This is a qualitative understanding research with ten Brazilian physicians from a private hospital. Participants were interviewed following a semi-structured script. From the data obtained in this research, results indicated that the surgical specialties or those in related fields had a higher error incidence. Classical medical training further reinforces a specific behavior by physicians that makes it difficult to ...
Open Access DOI:10.23937/2643-4466/1710015
Serpil Demirag, MD, PhD
Article Type: Research Article | First Published: July 03, 2019
The purpose of this study is to investigate the effect of medical education and training on medical student's knowledge, thoughts and attitudes to organ donation and transplantation, and also to draw attention to the subject. Totally 323 first and sixth grade students were included in this study. A questionnaire consisting of four categories and 48 questions was used to collect data. SPSS 18.0 program was used for the data input and the analyses of the study. A p value smaller than 0.05 was acce...
Open Access DOI:10.23937/2643-4466/1710014
Correlation between the Number and Magnitude of Howship Lacunes (HL) with the Blood Concentration of C-Ipth and CT in Patients with Advanced Chronic Kidney Disease Treated and Non-Treated with Regular Haemodialysis
Petar Cakalaroski, Ljutvi Zulbeari and Koco Cakalaroski
Article Type: Research Article | First Published: July 03, 2019
Seventy-one patients (71) with chronic kidney disease (CKD) (21 men and 18 females non-treated with hemodialysis and 19 men, respectively 13 females treated with regularly repeated hemodialysis) are investigated. The mean clearance of creatinin in investigated group were 0.17 mL/sec (10.2 mL/min). The average age of non-dialyzed group were 40.3 years, and in the dialyzed patients -38.6 years....
Open Access DOI:10.23937/2643-4466/1710013
Linda N Geng, Oliver Sum Ping and Yong-Jian Geng
Article Type: Commentary Article | First Published: May 20, 2019
Diagnostic journeys begin when patients first present to a healthcare provider for their symptoms and end when they receive the correct diagnosis for these symptoms. In many cases, the diagnosis can be made promptly, but patients with rare, complex, or unusual conditions often embark on odysseys spanning years to sometimes even decades in search of a diagnosis. This prolonged process can often result in excessive costs, preventable medical errors and iatrogenesis, as well as feelings of frustrat...
Open Access DOI:10.23937/2643-4466/1710012
Antoine El Khoury, Majd Roustom, Henri Azar, Georges Chaer and Tony El Murr
Article Type: Case Report | First Published: May 01, 2019
Appendagitis has always been considered as a diagnosis of exclusion. Most of the times it is diagnosed incidentally. The majority of patients present flank pain, right and/or left iliac fossa pain with few other symptoms. These findings lead usually the physician toward a surgical disease. Imaging is very important to confirm the diagnosis of appendagitis and to avoid unnecessary hospitalizations and surgeries. In this article, we present five cases of acute appendagitis that have had nearly sim...
Open Access DOI:10.23937/IAIM-2017/1710011
Dario Buccheri and Daniele Adorno
Article Type: Commentary article | First Published: February 20, 2019
Spontaneous dissection of the coronary artery (SCAD) is an uncommon cause of acute coronary syndrome (ACS) and is defined as a dissection of the coronary artery not associated with an atherosclerotic process, plaque rupture and/or thrombus formation and, by definition, not iatrogenic. The resulting myocardial damage is determined not by the rupture of a plaque indeed, but by the formation of an intramural hematoma (IMH) or intimal/medial disruption that determines the dissection of the arterial ...
Open Access DOI:10.23937/iaim-2017/1710010
Abrar-Ahmad ZULFIQAR MD, MSc and Marphy KERIF MD
Article Type: Brief Report | First Published: December 31, 2018
Data on ST elevation myocardial infarction in patients aged over 75 years remains sporadic. The prognosis for ST Segment Elevation Myocardial Infarction (STEMI) patients is bleak. Mortality at one year in patients aged over 80 years is very high. We describe a series of elderly patients over 75 years treated by emergency physicians in pre-admissions or in emergency wards presenting with acute ST elevation myocardial infarction, and we compare these data with a second group of patients aged below...
Open Access DOI:10.23937/iaim-2017/1710009
Sara Melboucy-Belkhir, Reda Khentache, Laure Andre-Ledun and Benoit Brihaye
Article Type: Case Report | First Published: November 21, 2018
Eosinophilic ascites is a rare presentation of eosinophilic gastroenteritis (EGE), a rare condition first described by Kaijser, in 1937; Hundreds of cases have been reported. EGE affects both adults and children. EGE was defined by the presence of gastrointestinal symptoms with an abnormal eosinophilic infiltrate of the intestine wall and exclusion of other causes of secondary eosinophilic infiltration; EGE has 3 clinical presentations depending on the depth of eosinophilic infiltration of the b...
Open Access DOI:10.23937/iaim-2017/1710008
S Melboucy-Belkhir, F Brigant, R Khentache, M Bouketouche, R Garidi and B Brihaye
Article Type: Case Report | First Published: November 21, 2018
Sweet syndrome also known as acute febrile neutrophilic dermatosis includes sudden onset of painful erythematous plaques, papules or nodules, fever, histopathological finding of neutrophilic infiltrate in the dermis without leukocytoclastic vasculitis and good response to systemic corticosteroids. Sweet syndrome may be linked to various conditions: Hematologic malignancies including myeloproliferative disorders, solid cancers, medications, Crohn diseases, colitis ulcerative, and autoimmune disea...
Open Access DOI:10.23937/iaim-2017/1710007
Article Type: Short Review | First Published: October 27, 2018
Constrictive pericarditis (CP) is characterized by impaired ventricular filling secondary to a scarred pericardium. The scarred pericardium involving both parietal and visceral layers may be thickened or calcified with resultant loss of normal elasticity of the pericardial sac. The common causes include idiopathic aetiology, post cardiac surgery and systemic diseases affecting the pericardium such as tuberculosis, collagen vascular diseases, malignancy, renal diseases or radiation therapy....
Open Access DOI:10.23937/iaim-2017/1710006
Annika Silfvast-Kaiser, Amanda Abramson Lloyd and Alan Menter
Article Type: Case Report | First Published: October 12, 2018
Angiosarcoma is a soft tissue sarcoma of endothelial origin that can arise in any organ, with an incidence of up to 5% of all malignant cutaneous tumors. It is the 4th most common sarcoma of the skin and typically occurs on the scalp of white men over 60 years of age. Its prognosis is traditionally very poor, with 5-year survival rates reported as low as 11%. Risk factors for cutaneous angiosarcoma have not been clearly established. Herein, we describe a 64-year-old male with a chronic history o...
Open Access DOI:10.23937/IAIM-2017/1710005
Zafer Pekkolay, Emre Aydin and Faruk Kilinc
Article Type: Research Article | First Published: September 29, 2018
Secondary hyperparathyroidism is associated with impaired calcium, phosphorus and vitamin D balance in patients with chronic renal insufficiency, and patients are often treated medically. However, some patients have medical treatment resistance. The definition of resistant renal hyperparathyroidism despite intake of calcimimetic, parathormon binding and vitamin D analogs persistent parathormon elevation and related symptoms. The only treatment for resistant renal hyperparathyroidism is surgery. ...
Open Access DOI:10.23937/iaim-2017/1710004
Moreno Diaz Javier, García Brunen Jose Miguel, Loscos Aranda Silvia and Arenas Miquelez Aranzazu Inmaculada
Article Type: CASE REPOR | First Published: September 07, 2018
Lemierre's syndrome is a rare complication of tonsillitis, with septic emboli and jugular vein thrombosis. We present a case in a young adult without immune deficiencies that required purulent collection drainage and admission to the Intensive Care Unit. This entity, although rare, is potentially fatal and should be known for early diagnosis and treatment....
Open Access DOI:10.23937/iaim-2017/1710003
Article Type: Review Article | First Published: November 27, 2017
There is a growing amount of the research data confirming the cancer risk associated with cooking starchy foods at high temperatures. In a word, acrylamide is a chemical used in lots of industrial processes, including water purification, or to separation of DNA molecules in experiments....
Open Access DOI:10.23937/iaim-2017/1710002
Richard Rissmiller and W Ennis James
Article Type: Review Article | First Published: September 18, 2017
Sarcoidosis is a granulomatous disease of unknown etiology that can affect any organ. Management of sarcoidosis patients with the potential for multi-organ involvement can be complex and require the expertise of multiple specialties. The goal of this review is to discuss clinical, imaging and epidemiologic features of organ involvement in sarcoidosis....
Open Access DOI:10.23937/iaim-2017/1710001
Jesus Peteiro and Alberto Bouzas-Mosquera
Article Type: Review Article | First Published: August 31, 2017
Stress echocardiography is an established tool for clinical assessment and decision making-process in patients with Coronary Artery Disease (CAD). Current indications include diagnosis and assessment of patients with suspected CAD and intermediate pre-test probability of the disease, assessment of patients with already known CAD, and diagnosis and assessment of patients with non diagnostic ECGs or with inconclusive exercise ECG tests....
All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.
Contact our editorial office