Factors Predicting Response to Neoadjuvant Therapy of Hepatic Metastasis from Colorectal Carcinoma
D. Cortes Guira,, MJ Fernandez-Acenero, Damian Garcia-Olmo and C. Pastor Idoate
Article Type: Review Article | First Published: September 03, 2015
Neoadjuvant chemotherapy (NAC) is a widely used therapeutic option for patients with resectable hepatic metastasis from colorectal carcinoma. In this setting, the intent of NAC is to reduce metastatic size and make surgery easier and/or less extensive, mostly in patients that are amenable to surgery. Several studies confirm that response to neoadjuvant therapy is indicative of a better prognosis for such patients and several methods have been proposed and validated to measure both radiological a...
Ovarian Neoplasm in a Patient with Prior Breast Carcinoma - Challenges and Pitfalls in Diagnostic Process
Elena Arabadzhieva, Sasho Bonev, Lyubomira Dimitrova, Atanas Yonkov, Dimitar Bulanov, Vesela Ivanova and Violeta Dimitrova
Article Type: Case Report | First Published: September 02, 2015
We present a case of 58-year-old woman who underwent bilateral adnexectomy with small bowel resection during urgent operation for an incarcerated umbilical hernia. There was a slight enlargement in both ovaries and presence of cystic formation with some papillary structures in the right one. Histologically, bilateral infiltration of tumor cells with moderate cytological and nuclear atypia and tubular, nested and cystic growth pattern was observed. The patient had a long list of co-morbidities: l...
The Optimization of Igm In-House ELISA for the Laboratory Diagnosis of Melioidosis in Malaysia
Azura Mohd Noor, Norazah Ahmad and Wan Rozita Wan Mahiyuddin
Article Type: Research Article | First Published: September 02, 2015
Melioidosis is a life-threatening infectious disease which can lead to high mortality and death within 48 hours if treatment is delayed. Detection of antibodies against Burkholderia pseudomallei may help in early diagnosis of melioidosis. This study was carried out to optimize an in-house ELISA for the detection of Immunoglobulin M (IgM) against B. pseudomallei in suspected acute melioidosis patients in Malaysia. Three different concentrations of crude B. pseudomallei cells antigen (0.200 mg/ml,...
Sleep Characteristics in Blind Subjects
Fructuoso Ayala-Guerrero and Graciela Mexicano
Article Type: Research Article | First Published: September 14, 2015
The sleep patterns of ten blind adults and their matched controls were studied during three consecutive nights. The first night was allowed for adaptation. Significant electroencephalographic and quantitative findings were obtained from nights 2 and 3. Although alpha-like rhythm was registered in only one blind subject during wakefulness, it was displayed by 8 of the 10 blind participants of this study during REM sleep. This rhythm was also present during the N2 sleep stage. The delta phase of s...
Marked Increases in Alpha Power Over the Left Prefrontal Region During Days Following Shift Work: A Case Report
Nirosha J. Murugan, Nicolas Rouleau, Lukasz M. Karbowski, Andrew P. Lapointe and Michael A. Persinger
Article Type: Case Report | First Published: September 10, 2015
Quantitative electroencephalographic (QEEG) measurements were completed for a 35 year old of paramedic following two to five days of shift change and rest periods. The most conspicuous and reliable change was a marked increase (factor of 5) in power within the alpha band over the left prefrontal region and, to a lesser degree, increased power within the low-beta band over the right parietal region during the test periods after no work days. These results indicate that regions of cerebral cortice...
Association of SORL1 Polymorphisms with the Risk of Amnestic Mild Cognitive Impairment in the Han Chinese Population
Lili Zhang, Xiaowei Liu, Bailing Wang, Qing Xu, Jianzhong Zhu, Feng Zhang and Chunhui Jin
Article Type: Communication | First Published: September 14, 2015
Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage, characterized by cognitive impairment that is not severe enough to influence the usual activities of daily living. MCI is suggested to be a transitional state between healthy aging and clinically probable Alzheimer's disease (AD). Previous studies have identified that single nucleotide polymorphisms (SNPs) in the sortilin-related receptor, L (DLR class) A repeats containing (SORL1) gene are associated with amnestic ...
Bayesian Survival Analysis of Genetic Variants in PTPRN2 Gene for Age at Onset of Cancer
Ke-Sheng Wang, Yue Pan, Weize Wang and Chun Xu
Article Type: Research Article | First Published: September 9, 2015
The protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) gene may play a role in cancer; however, no study has focused on the associations of genetic variants within the PTPRN2 gene with age at onset (AAO) of cancer. Methods: This study examined 220 single nucleotide polymorphisms (SNPs) within the PTPRN2 gene in the Marshfield sample with 716 cancer cases (any diagnosed cancer, excluding minor skin cancer) and 2,848 non-cancer controls. Multiple logistic regression model and li...
A Review of Graphical Approaches to Common Statistical Analyses. The Omnipresence of Latent Variables in Statistics
Emil N. Coman, L. Suzanne Suggs, Maria Coman and Eugen Iordache and Judith Fifield
Article Type: Review Article | First Published: September 4, 2015
We provide a comprehensive review of simple and advanced statistical analyses using an intuitive visual approach explicitly modeling Latent Variables (LV), likely to better illuminate what is assumed in each analytical method and what is actually estimated, by translating the causal relationships embedded in the graphical models in equation form. We recommend the graphical display rooted in the century old path analysis, that details all parameters of each statistical model, and suggest labeling...
Drug Treatment Comparison for Total Knee Replacement Surgery
Kevin Soderholm and Rhonda Magel
Article Type: Research Article | First Published: September 02, 2015
Data from over 2000 patients receiving knee replacement surgery was gathered from a hospital system in the Midwestern United States. The age group that each patient belonged to was noted, under age 65 or 65 years of age and older, as well as their gender. A variety of drugs in each of three drug categories was studied as to their association with total hospital cost, length of stay, prevalence of early readmissions and prevalence of blood transfusions. The drug categories included spinal blocks,...
Coexisting Normal- Tension Glaucoma and Deficiencies of Folic Acid and Vitamin B6 (Pyridoxal)
Article Type: Case Report | First Published: September 06, 2015
A 43-year-old man presented with bilateral visual field defect. Large disc cupping, retinal nerve fiber layer defect, and normal intraocular pressure were found in both eyes. Although the patient was prescribed an anti-glaucoma eye drop, the visual field defect deteriorated after two months of treatment. The patient was diagnosed with sensory, taste, and hearing impairments, as well as depression, caused by folic acid and vitamin B6 (pyridoxal) deficiencies at an internal medicine department. Th...