Prevalence of Hypertensive Emergency in Emergency Room of Rajavithi Hospital
Sumitra Piyanuttapull and Jaruboot Angsanakul
Article Type: Research Article | First Published: April 09, 2016
Hypertensive crisis is common among patients visiting emergency room (ER). Majority of these patients can be treated on an outpatient basis (hypertensive urgency). Other patients have acute end-organ damage and higher morbidity and mortality (hypertensive emergency). However, no study on the prevalence of hypertensive emergency in ER in Thailand was found. We aim to evaluate the prevalence and also potential predictors of hypertensive emergency....
Noninvasive Tools Used Nowadays in both, Clinical Practice and Trials in Order to Assess Blood Pressure
Martyna Zaleska, Olga Mozenska, Katarzyna Nikelewska, Magdalena Chrabaszcz, Weronika Rygier, Jan Gieraltowski, Monika Petelczyc and Dariusz A Kosior
Article Type: Short Review | First Published: April 02, 2016
Hypertension affects currently around 1 billion people worldwide and cardiovascular disease remains the most frequent cause of mortality worldwide. Hypertension societies publish cyclically recommendations how to diagnose and manage this illness. Some of them describes tools used to diagnose this disease, others do not. However nowadays many new methods are introduced to assess blood pressure (BP) values. Some of them allow only to obtain central or systolic BP, others are used currently only in...
Cellular Rhinitis: A Therapeutic Proposal
A Macchi, F De Bernardi, A Peirolo and D Simoncini
Article Type: Original Article | First Published: May 01, 2016
Rhinitis, a common condition throughout the world, are classified in non-allergic (NAR) and allergic rhinitis (AR). The data collected by recent studies show that NAR affects more than 200 million patients world-wide, among which 8% to 10% suffer from NARES and NARESMA. Nevertheless, respiratory diseases, and in particular rhinitis, are not considered real and serious diseases, and, as a result, they remain frequently underdiagnosed and undertreated despite the heavy burden they place on patient...
An Unusual Complication of Maxillary Subperiosteal Implant Removal: Dislocation of the Parotid Gland Duct
Marciante Giulia Anna, Saibene Alberto Maria, Pisani Antonia, Biglioli Federico and Giovanni Felisati
Article Type: Case Report | First Published: April 30, 2016
A 73-year-old man, treated with a maxillary subperiosteal implant in 1985, was referred to our ENT clinic by his dental practitioner due to the onset of sudden edema, pain and purulent nasal discharge. Although the patient had experienced painful recurrent mobilization of the implant from 1995, he did not approach his dentist until 2006, when edema and purulent nasal discharge occurred. The radiologic imaging revealed a maxillary sinusitis with severe maxillary bone resorption and an oro-nasal/o...
Short Term Quality of Life Following Transcatheter Aortic Valve Replacement
Yaar Aga, Ximena Marincic, Christian Marin y Kall, Peter de Jaegere and Eduardo De Marchena
Article Type: Research Article | First Published: April 01, 2016
Transcatheter Aortic Valve Replacement (TAVR) has emerged as an alternative treatment modality for patients with severe aortic stenosis (AS) who are at high or extreme risk for surgical aortic valve replacement (SAVR). Previous studies have shown that TAVR results in substantial reductions in symptoms and mortality. Despite these health benefits, the assessment of quality of life (QOL) remains critical in these patients who often express quality of life over quantity of life....
Facial Follicular Mucinosis in Adolescence
Gokce Isil Kurmus, Filiz Canpolat, Muzeyyen Gonul and Murat Alper
Article Type: Case Report | First Published: April 12, 2016
Follicular mucinosis (FM), also known as alopecia mucinosa, is a rare inflammatory disorder that characteristically presents as follicular papules or infiltrated plaques with prominent follicular openings associated with alopecia. Histologically, the disorder is characterized by mucin deposition in the follicular epithelium and sebaceous glands. FM was classified in two distinct entities: a primary or idiopathic form, usually presents in children and young adults with a benign course, and a seco...
New Insights and Therapeutic Implications in Cutaneous Melanoma
Pinar Ozuguz, Seval Dogruk Kaca and Serap Polat
Article Type: Review Article | First Published: April 11, 2016
Melanoma is a highly aggressive tumour with poor prognosis in the metastatic stage that arises and evolves due to a myriad of genetic and epigenetic events. Among these, the interaction between epigenetic alterations (i.e., DNA methylation, histone modifications, mRNA silencing by miRNAs and nucleosome repositioning) has been recently identified as playing an important role in melanoma development and progression by affecting key cellular pathways such as cell cycle regulation, DNA repair, apopt...
Targeted Prodrug Design for the Treatment of Malignant Melanoma
Marcella Gabrielle Mendes Machado, Paulo Renato Yamasaki, Jean Leandro dos Santos and Chung Man Chin
Article Type: Short Review | First Published: April 04, 2016
Malignant melanoma is a serious health problem once the current chemotherapy exhibits resistance to traditional drugs. Several challenges must be overcome during drug design in order to increase the efficacy and safety of the new drugs. Therefore, the specific chemical release of cytotoxic agents near to the target is an attractive approach to improve the anticancer activity and reduce the systemic toxicity. Herein, this review article describes the advances in the development of targeted prodru...
Comparative Study of Laparoscopic Versus Open Resection of Colorectal Liver Metastasis
Christian Hunnicke Petersen, Peter Norgaard Larsen, Jan Storkholm, Nicolai Aagaard Schultz and Kenneth Hojsgaard Jensen
Article Type: Original Article | First Published: March 30, 2016
Laparoscopic liver resection is gaining increased application in the treatment of colorectal liver metastases (CRLM). The aim of this study is to compare safety and feasibility of minor laparoscopic liver resection vs. open liver resection in patients with CRLM. One hundred and twenty-eight patients who underwent minor resection of CRLM were retrospectively reviewed. Sixty-four consecutive cases of laparoscopic liver resections (LLR) were compared to a matched control group of 64 open liver rese...
Platelet to Lymphocyte Ratio as a Novel Prognostic Marker in Male Patients with Chronic Obstructive Pulmonary Disease
Sezgi Sahin Duyar, Yalcin Solak, Dilek Tekis, Jale Karakaya, Ferit Kuscu and Asuman Erarslan
Article Type: Original Article | First Published: March 31, 2016
Neutrophil to lymphocyte ratio(NLR) and platalet to lymphocyte ratio (PLR) are recently defined novel inflammatory markers which are readily available. Their prognostic signifigance has been shown for a number of inflammatory diseases. A recent study evaluated the role of NLR in patients with chronic obstructive pulmonary disease(COPD). Thus, we aimed to investigate the relations between NLR, PLR and severity of COPD in male patients who had stable disease....