Cocaine Induced ANCA Negative Vasculitis - A Diagnostic Dilemma!
Kunal Bhuta, Kriti Devkota2 and Haris Mobeen
Article Type: Case Series | First Published: April 24, 2022
Cocaine is an addictive stimulant drug. In 2014, about 913,000 Americans met the Diagnostic and Statistical Manual of Mental Disorders criteria for dependence or abuse of cocaine. Approximately 69% of Cocaine has been contaminated with Levamisole. Levamisole has been found to be immunogenic causing anti-neutrophil cyto-plasmic antibody (ANCA)-associated cutaneous vasculitis in 88-100% patients. 24-year-old male with a history of polysubstance abuse including IV drug abuse presented with complain...
Isothermal Amplification-Based Detection Platforms for Pathogenic Leptospira Species in Flood and Environmental Waters
Rubigilda Paraguison-Alili, Renmar M Dela Cruz, Analiza M Balaga and Winston A Palasi
Article Type: Original Article | First Published: April 27, 2022
Detecting the occurrence of pathogenic Leptospira spp. is vital for public health implications and epidemiological studies. Different isothermal-based techniques ascribed to loop-mediated isothermal amplification (LAMP) to detect Leptospira spp. in black rats and spiked environmental waters were evaluated. In this study, modified platforms were designed to detect the lipL32 gene encoding the major outer membrane lipoprotein of Leptospira spp. Standard and direct dry isothermal technique platform...
Neuromuscular Electric Stimulation as an Alternative to Dynamic Warm-Up for Anaerobic Power Activities
Jason Wicke, Ben Chianchiano, Sara Garner and Jordan L Cola
Article Type: Scientific Research | First Published: April 14, 2022
The aim of this study was to compare short duration Neuromuscular Electric Stimulation (NMES) to traditional dynamic warm-up to prepare muscles for activity. Thirty college age participants (20 male, 10 female) completed both a general warm-up, followed by either an NMES warm-up or a dynamic warm-up. The participants were then asked to perform three trials each of standing long jump, 20m sprint, and 18.3m (20-yard) shuttle run, in random order. Each participant returned one week later and were t...
Follicular Mucinosis in Childhood: A Rare, but Significant Diagnosis
Maria Luiza Cimardi Rupp, Marice El Achkar Mello, MD, Amanda Amaro Pereira, MD, Maria Marlene de Souza Pires, MD, PhD
Article Type: Case Report | First Published: April 21, 2022
Follicular mucinosis (FM) is a rare cutaneous disease with unclear etiology; it was firstly described by Pinkus, et al. in 1957, who named it mucinous alopecia, referring to a characteristic process of the FM, which leads to alopecia. As this process was not seen on all developments of the disease, in 1959 Jablonska, et al. proposed to name it Follicular mucinosis. Follicular mucinosis is uncommon in children. Using the online searching databases Scielo and PubMed, during the past 10 years, only...
The Rare Disease Advisory Council Expands its Reach into West Virginia Appalachia: A Call to Action
Nadia Falah, MD
Article Type: Letter to the Editor | First Published: April 21, 2022
Patients with rare diseases in rural Appalachia face an additional hurdle in getting care. West Virginia is the only state wholly within the Appalachian region, which is noted for having some of the nation's worst health disparities. The West Virginia Advisory Council on Rare Diseases was established in January 2020 as part of the Rare Disease Advisory Council (RDAC) Acts, with the goal of developing strategies and recommendations to reduce health inequalities among West Virginians with rare dis...
Variants in TBCK cause Global Developmental Delay, Dysmorphism, Hypotonia
Maha Alotaibi and Shaza M Aloulou
Article Type: Case Series | First Published: April 25, 2022
A protein kinase domain, a Rhodanase-like domain, and the Tre-2/Bub2/Cdc16 (TBC) domain are all encoded by the TBCK gene. By modulating the mammalian target of rapamycin (mTOR) signaling pathway, the encoded protein is hypothesized to play a role in actin organization, cell growth, and cell proliferation. Has a role in the organization of the actin cytoskeleton. This protein may also play a role in the transcriptional control of mTOR complex components. And it’s found practically everywhere, i...
Paracetamol Poisoning: Need to Remember Nephrotoxicity
Inês Rosinha, Marta Machado, Carolina Cordinhã, Carmen Do Carmo and Clara Gomes
Article Type: Case Series | First Published: April 11, 2022
Paracetamol overdose is an important cause of drug toxicity and pediatric overdose emergencies remain a significant global issue. Paracetamol is a known toxin to several tissues, but extrahepatic manifestations are not so well established as hepatotoxicity. Acute kidney injury occurs in up to 2% of paracetamol overdoses, generally coexisting with hepatotoxicity. A 14-year-old female adolescent presented to the emergency department 24 hours after a purposeful overdose of 22.5 grams of paracetamol...
The “Giant” Median Nerve, a Rare Diagnosis Presenting as Routine Carpal Tunnel Syndrome: Case Series and Literature Review
Jennifer Tram, BS and Kenneth Vitale, MD
Article Type: Case Study | First Published: April 07, 2022
Carpal tunnel syndrome is one of the most common entrapment neuropathies and is caused by median nerve compression as it traverses the carpal tunnel. Marked enlargement of the median nerve in the setting of carpal tunnel syndrome, occasionally termed “giant” median nerve, is rare in the literature and typically seen only in conditions of tumorous growth or arteritis. Here we report two cases of a giant median nerve in the setting of carpal tunnel syndrome. One patient reported classic sensor...
Long-Term Retrospective Survival of Dental Implant Therapy
Didem Özkal Eminoğlu, Sema Nur Sevinç Gül, Tuğba Aydin and Gurbet Alev Öztaş Şahiner
Article Type: Research Article | First Published: March 31, 2022
The aim of this study is to determine the prevalence of implants with progressive bone loss after a 5-year follow-up. A total of 437 patients with 1814 dental implants placed at XXX University Dentistry Faculty, YYY, ZZZ; between 2014-2019 has included to study. Implants with radiographic bone loss of 2 mm or more were assessed as peri-implantitis (PI). Longitudinal data were collected retrospectively from digital dental records. SPSS 20.0 package program was used to analyze the collected data. ...
STEMI during Cardiocerebral Infarction (CCI): Is it Safe to Perform Primary Percutaneous Coronary Intervention?
Thon Hon Yong, Jia Hao Jason See and Boon Wah Liew
Article Type: Case Series | First Published: April 14, 2022
Emergency percutaneous coronary intervention (PCI) is a critically important reperfusion strategy for myocardial salvage in the event of acute ST elevation myocardial infarction (STEMI). However, it poses great challenges to the treating cardiologist if there is a simultaneous acute cerebral infarction because of potential intracranial complications. Particularly, the use of dual antiplatelet and high dose anticoagulants during PCI has been well documented to increase the risk for cerebral hemor...