Journal of Toxicology and Risk Assessment is a global, open access, peer reviewed journal that publishes wide variety articles on all the aspects of the adverse effects of chemical, physical, or biological agents on people and the environment and assessing the risk involved. JTRA provides forum for publication, education, and exchange of opinions globally. It acts as a platform for the authors to contribute their findings and help raise awareness among community on toxicity assessment and prevention. We aim to provide free, immediate and unlimited access to highest quality clinical content via open access platform.

Journal of Toxicology and Risk Assessment provides research updates on Basic Toxicology, Public Health Toxicology, Environmental Toxicology, Computational Toxicology, Forensic Toxicology, Toxicology of Natural Products, Chemotherapy, Hepatoxic, Nephrotoxic and Neurotoxic Agents, Immunopharmacology and Immunotoxicology, Toxicogenomics, Risk Assessment, Risk Management, Aquatic Toxicology, Automatism (Toxicology), Ecotoxicology, Entomotoxicology, Enzyme Inhibition, Forensic Toxicology, In vitro Toxicology, Indicative Limit Value, Medical Toxicology, Modes of Toxic Action, Overdose, Pollution, Toxicity, Toxicology Mechanisms and Methods, Toxinology, etc. All formats of articles viz., original Article, Reviews, Mini Reviews, Short Communications, Case Reports, Perspectives/Opinions, Letters, Short Note and Commentaries are accepted for publication. All articles published in the journal are subject to a rigorous peer review process.

Journal Information

Title: International Journal of Toxicology and Risk Assessment

ISSN: 2572-4061

Editor-in-chief: Lu Cai

NLM title abbreviation: J Toxicol Risk Assess

ISO abbreviation: J Toxicol Risk Assess

Other titles: IJTRA

Category: Biological Science

DOI: 10.23937/2572-4061

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Publication type(s): Periodicals

Publisher: ClinMed International Library

Country of publication: USA

Language: English

Contact email:

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI


 Open Access DOI:10.23937/2572-4061.1510012

Enhancing the Raman Scattering for Diagnosis and Treatment of Human Cancer Cells, Tissues and Tumors using Cadmium Oxide (Cdo) Nanoparticles

Alireza Heidari

Article Type: Research Article | First Published: September 28, 2018

In the current paper, the Localized Surface Plasmon Resonance (LSPR) effect induced by Cadmium Oxide (CdO) nanoparticles is used to observe Raman spectrum of human cancer cells, tissues and tumors. The diagnosis and treatment of human cancer cells, tissues and tumors in sample is investigated through Nanomaterial Surface Energy Transfer (NSET) process from human cancer cells, tissues and tumors to the surface of nanoparticles, and Surface Enhance...

 Open Access DOI:10.23937/2572-4061.1510011

Demonstrated Spatial Irrelevance of Gray Fox at Contaminated Sites: Are Ecological Risk Assessments for Mammals Necessary?

Lawrence V Tannenbaum, David M Bullis, Nicholas R Deuel, L Mike Conner, Michael J Chamberlain and Karl V Miller

Article Type: Research Article | First Published: June 30, 2018

Ecological risk assessments (ERAs) for contaminated terrestrial sites regularly include mammals as receptors-of-concern whose home ranges dwarf the sites by tens of times. As a consequence, opportunities to sustain chemical exposures of concern are greatly limited. In having notably miniscule densities as well, wide-ranging mammals are poorly selected species to evaluate because true populations are effectively non-existent at sites. Collectively...

 Open Access DOI:10.23937/2572-4061.1510010

Recent Advances in Mercury Detection; Towards Enabling a Sensitive and Rapid Point-of-Check Measurement

Nurfatini Busairi and Amir Syahir

Article Type: Research Article | First Published: April 09, 2018

Heavy metals emission, in particular, mercury is ever increasing due to global urbanization and industrialization. Due to increasing number of health problems related to heavy metals contamination, monitoring it becomes a crucial task for authorities and environmentalists. Therefore, the development of a nanobiosensing technique that can detect mercury ions as low as 1 ppb for its limit of quantification is necessary to provide sufficient informa...

 Open Access DOI:10.23937/2572-4061.1510009

Evaluation of In Vitro Cytotoxicity of Zinc Oxide (Zno) Nanoparticles Using Human Cell Lines

A Rama Narsimha Reddy and L Srividya

Article Type: Research Article | First Published: March 16, 2018

The aim of the present study was to evaluate the in vitro toxicity of Zinc Oxide (ZnO) nanoparticles against human alveolar epithelial (A549) cells and human embryonic kidney cells (HEK cells). The toxic effects of nanoparticles were analyzed after 24 hours of incubation with different cell lines using trypan blue dye exclusion method....

 Open Access DOI:10.23937/2572-4061.1510008

Assessment of Environmental Contamination by Wastewater from a Cocoa Processing Industry Using Genetic and Reproductive Biomarkers

Alabi A Okunola, Esan E Babatunde, Olorunfunmi J Temitope and Oludare O Evelyn

Article Type: Research Article | First Published: September 25, 2017

Food industries are among the major contributors to industrial wastes. Their wastewaters can pose a threat if untreated and indiscriminately disposed into the environment. In this study, we investigated the potential genetic and reproductive toxicity of Cocoa processing industry wastewater, by using the mouse Micronucleus (MN) and sperm morphology assays....

 Open Access DOI:10.23937/2572-4061.1510007

Accuracy of Admission Glasgow Coma Scale to Predict Aspiration Pneumonia in Poisoned Patients

Sebastien Champion and Vincent Spagnoli

Article Type: Short Commentary | First Published: August 01, 2017

Glasgow Coma Scale (GCS) assesses the need and guides tracheal intubation in trauma patients. GCS provides a practical method for assessment of impairment of conscious level in response to defined stimuli. GCS is the sum of 3 sub-scores for eye opening (1 to 4), verbal (1 to 5), and best motor (1 to 6) response to stimulations....

 Open Access DOI:10.23937/2572-4061.1510006

Is There any Relationship between Worldwide Pesticide Standard Values in Residential Soil, Drinking Water, and Agricultural Commodity Exposures?

Zijian Li and Aaron A Jennings

Article Type: Research Article | First Published: June 24, 2017

Human could exposure to pesticides via various exposure pathways. Worldwide jurisdictions are making efforts to manage human health risk by regulating pesticide standards in residential soil, drinking water, and agricultural commodity....

 Open Access DOI:10.23937/2572-4061.1510005

Suppression of Calpain-2 by Small Interfering RNA Inhibits Hydrogen Peroxide-Induced Apoptosis in Rat Pancreatic Acinar Cells AR42J

Bettina Hiemer, Alisa Bernert, Frederic LP Gabriel, Michael Wakileh and Heike Weber

Article Type: Research Article | First Published: May 19, 2017

Apoptosis is defined as controlled programmed cell death that occurs as physiological process in the development and morphogenesis of multi-cellular organisms, but is also implicated in various diseases, including acute pancreatitis. Apoptosis can be induced by a wide range of stimuli....

 Open Access DOI:10.23937/2572-4061.1510004

Drug-facilitated Crime: A Diagnosis to Remember in the Emergency Department

Rocca F D, Pignatiello F, Casacanditella G, Tucci M and Favretto D

Article Type: Case Report | First Published: January 25, 2016

We report on a case of a young man arrived to the emergency department (ED) of the local hospital in a sleepy, confused state, and exhibiting anterograde amnesia. He reported to have been robbed. Toxicological analysis performed in his blood sample with a general unknown screening procedure including mass spectrometry detection revealed the presence of zolpidem....

 Open Access DOI:10.23937/2572-4061.1510003

Long-Term Effects on Renal Function in Children and Adolescents Due to Environmental Exposure to Lead-Results from an 11-Year Prospective Cohort Study

Recio-Vega R, Gurrola-Mendez A, Valdez-Abrego C and Rivera-Guillen Mario

Article Type: Research Article | First Published: December 31, 2015

Lead is a widespread toxicant with well-established detrimental health effects. Environmental exposure to lead occurs through different means such as industrial and combustion sources, lead paint, folk remedies, glazed pottery, and sometimes by drinking water. Some groups are disproportionately exposed to lead, including those who live close to industrial facilities or with low socio economic status and workers in small or mobile workplaces such ...

 Open Access DOI:10.23937/2572-4061.1510002

Hydroxypyrene Excretion as Indicator of Cancer Risk in Street Sweepers and Polycyclic Aromatic Hydrocarbons (Pahs) Exposure

Mazzotta M, Mazzotta AD, d'Ettorre G, Cazzato RG, Simone C and Fernandez M

Article Type: Research Article | First Published: December 16, 2015

Exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with possible carcinogenicity, according to European directives. Studies helped to clarify the contributions to the total dose resulting from environmental and occupational exposure, by tobacco smoke, by diet and skin absorption. Recently, it was shown that levels of 1-Hydroxypyrene U (1-OHPu) may be predictive of individual dose, environmental and employment exposure, proportionat...

 Open Access DOI:10.23937/2572-4061.1510001

Micronuclei Induction and Neurotoxic Effect in C6 Glioma Cells Exposed to Low Concentrations of Diazinon, an Organophosphorus Compound

Carla Falugi, Chiara Gambardella, Tommaso Bonfiglio, Zoltan Rakonczay, Federico Biggi, Sara Novelli and Mariangela Masini

Article Type: Original Article | First Published: August 26, 2015

Even though the adverse effects on environment and organism health have been long and thoroughly studied, the problem represented by the continuous use of neurotoxic pesticides, in particular organophosphates (OPs, organic salts of the pyro phosphoric acid), is still open. These are considered as emerging pollutants, as their massive employment is relatively recent, dating after the ban of persistent organic pesticides. OPs are not persistent for...


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