International Journal of Oncology Research is an open access, peer reviewed, multidisciplinary journal focused to publish articles on developments of all types of malignancies including pathology, diagnosis and therapy, including radiotherapy, and systemic treatment. Articles submitted to the journal will be subjected to standard peer review process to ensure the quality of submitted content.

The journal invites significant and up-to-date articles within the fields of experimental and clinical oncology. The articles on aspects covering apoptosis, biotherapeutics, bone marrow transplantation, cancer biology, cancer epidemiology, cancer etiology, cancer prevention, cancer rehabiliation medicine, cancer screening and diagnosis, cell differentiation & proliferation, chemotherapeutic agents, clinical imaging, cytogenetics, emerging therapeutics, flow cytometry, general hematology and oncology, medical oncology, molecular biology module, neoplasms, oncologic emergencies, oncology nursing, principals of endocrine therapy, principles of cancer pathology, psyco oncology, radiation oncology, societal oncology, surgical oncology, transfusion medicine, tumor immunology, etc.

Journal Information

Title: International Journal of Oncology Research

ISSN: 2643-4563

Editor-in-chief: Osamu Tanaka

NLM title abbreviation: Int J Oncol Res

ISO abbreviation: Int J Oncol Res

Other titles: IJOR

Category: Oncology/Cancer

DOI: 10.23937/2643-4563

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Publication type(s): Periodicals

Publisher: ClinMed International Library

Country of publication: USA

Language: English

Contact email:

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI


 Open Access DOI:10.23937/2643-4563/1710055

RNA m6A Modifications and Cancer

Afrasiyab, Sadaf Ayaz, Peilin Zheng and Shoujun Huang

Article Type: Review Article | First Published: 2023/11/02

Epitranscriptomic modifications of RNA, particularly N6-methyladenosine (m6A), have emerged as pivotal players in cancer biology. RNA m6A modifications dynamically regulate gene expression, influencing various aspects of RNA processing, stability, and translation. In the context of cancer, dysregulation of RNA m6A modification has been implicated in tumorigenesis, metastasis, therapy resistance, and the tumor micro environment. ...

 Open Access DOI:10.23937/2643-4563/1710054

Rare Breast Cancer: Primary Melanoma of Breast Parenchyma

Mohamed Moneer Abulfotooh Alsayed, MSc, MRCS, Amal Yousif Saleh Abdullah, Ashraf Ahmed Abdeltawab Ibrahim, Ghaidaa Naser Abdul Razak, Sana Tabish and Rana Al Abdulghani

Article Type: Case Report | First Published: 2023/10/14

Melanoma is a highly aggressive cancer that can be cutaneous (most common) or mucosal, affecting the skin or mucous membranes at any organ in the body. It can also be found in the eye (uveal). Breast melanoma is rare, and it can manifest in one of three forms: 1) Metastatic secondary to primary melanoma at another site, 2) Primary cutaneous melanoma arising at the breast skin, or 3) Primary non-cutaneous melanoma arising in the breast parenchyma itself. ...

 Open Access DOI:10.23937/2643-4563/1710053

Liver Metastasis: Current Concepts in Management and Future Perspectives

Aditya Sharma, Ram Niwas Meena, Rahul Khanna and Seema Khanna

Article Type: Review Article | First Published: 2023/08/20

Liver metastasis can be defined as the seeding of a malignant tumour from other organs affected by cancer. About half of the patients with colorectal cancer develop liver metastases during the progressive course of the disease. Surgery is the only curative treatment for patients with metastatic liver disease, and the five-year survival rate after resection of all detectable liver metastases can be as high as 40%. Unfortunately, only 25% of patients with liver metastases are candidates for liver ...

 Open Access DOI:10.23937/2643-4563/1710052

Dose Variation Profiles of Small Fields with a 10 MV Photon Beam

Caio Fernando Teixeira Portela and Arnaldo Prata Mourão

Article Type: Original Article | First Published: 2023/05/20

Radiotherapy is a treatment of carcinogenic tumors using ionising radiation and the improvement of radiotherapy techniques has been conducted to protection of healthy tissues. Recent implementations have employed static fields with small dimensions. The interests for this work were small fields, used in modern techniques such as Stereotactic Radiation Therapy (SRS) and Intensity Modulated Radiation Therapy (IMRT). These fields have special characteristics that refer to the non-establishment of t...

 Open Access DOI:10.23937/2643-4563/1710051

Two Cases of Primary Leiomyosarcoma of the Vagina: Histomorphologic Presentation with Review of the Literature

Mouamba FG, Buambo RG, Mozoma L, Samba B, Bizib GC, Mavoungou K, Bizib GC, Senga B and Peko JF

Article Type: Case Report | First Published: March 16, 2023

Leiomyosarcoma is a rare lesion and its localization to the vagina extremely rare. We report two cases of primary leiomyasarcoma of the vagina, involving the posterior wall, in a 46-year-old woman and a 56-year-old woman, describing their histomorphological and evolutionary characteristics, with review of the literature....

 Open Access DOI:10.23937/2643-4563/1710050

Borderline Ovarian Tumors a Five-year Retrospective Clinicopathologic Study of 69 Cases in Egyptian NCI (2013-17)

Muhammad Adel Ali, Mohamed Abd El Fattah El Zohairy, Nesreen Hassan Hafez and Amr Kamal

Article Type: Retrospective Study | First Published: March 16, 2023

In the current study, we report our experience with borderline ovarian tumors. We collected and analyzed retrospective data on the pathology, management, disease free survival (DFS) of patients with borderline ovarian tumors (BOT) who underwent surgical management at or were referred to department of surgical oncology, National Cancer Institute, Cairo University (NCI) from January 2013 to December 2017....

 Open Access DOI:10.23937/2643-4563/1710049

Duodenal Metastasis of a Pulmonary Adenocarcinoma: Report of a Case and Review of the Literature

Maryam Zaouit, Nisrine Bennani Guebessii, Fadwa Oudad, Ayoub Khoaja, Imane Aaribi, Loubna Hejjane, Nadia Benchekroun, Souha Sahraoui and Abdellatif Benider

Article Type: Case Report | First Published: March 06, 2023

Symptomatic gastrointestinal metastases from lung cancer were considered quite rare given their low incidence, especially the duodenal location. In this article, we report a clinical case of a patient followed for a pulmonary adenocarcinoma revealed by a duodenal metastasis. The patient was a 63-year-old female. She was admitted to the oncology department of the Ibn Rochd University Hospital for a low digestive hemorrhage ‘’Melena’’ complicated by acute anemia....

 Open Access DOI:10.23937/2643-4563/1710048

Nodular Melanoma: A Case Report and Review of Literature

Ramon Eduardo Garcia Cahuich, Bianca Susana de la Torre Cuevas, Oscar Rene Vazquez Melo, Alondra Yereldi Naranjo Cruz and María Valeria Jiménez Báez

Article Type: Case Report | First Published: December 18, 2022

A malignant melanoma is an abnormal proliferation of pigmented cells in the body. Half of these tumors have BRAF mutations, with a worse response to treatment. We present the case of a 58-year-old male with a pigmented nodular lesion on the right calf and inguinal lymphadenopathy; a positive biopsy for nodular malignant melanoma (MMN) with the largest diameter of 2 mm, Clark level III and Breslow of 3 mm. Four months after tumor resection of the right pelvic limb and right lymphadenectomy are pe...

 Open Access DOI:10.23937/2643-4563/1710047

Impact of the Covid-19 Pandemic on the Lung Cancer Management Process at the Mohamed VI Center for the Treatment of Cancer in Morocco


Article Type: Original Article | First Published: November 06, 2022

Lung cancer being one of the main causes of mortality in Morocco, the coronavirus pandemic (COVID-19) has changed the processes of diagnosis and referral of lung cancer cases to oncology services. The objectives of this study were to describe the changes in the process of caring for lung cancer and to identify the activities affected during the COVID-19 pandemic in the Mohamed VI center for the treatment of cancers of the CHU IBN ROCHD of Casablanca in Morocco....

 Open Access DOI:10.23937/2643-4563/1710046

Impact of Quality of Life on Prognosis of Metastatic Non- Small Cell Lung Cancer: Is It Correlated to the Chemotherapy Regimen Used?

Nidhal Belloumi, Chaima Habouria, Hana Mrassi, Malak Maamar, Imen Bachouch, Fatma Chermiti and Soraya Fenniche

Article Type: Original Article | First Published: October 05, 2022

Interactions between cancer genesis, sleep quality and patient’s humor engage complex pathophysiological pathways. However, the outcome of various indicators of quality of life (Qol) after chemotherapy in non small cells lung cancer (NSCLC) and also their prognostic impact remain understudied. The objective of this study was to analyze the Qol, sleep quality and anxio-depressive disorder in advanced NSCLC patients put on chemotherapy....

 Open Access DOI:10.23937/2643-4563/1710045

Leiomyosarcoma of the Inferior Vena Cava Presenting as a Renal Mass: A Case Report

Hind Saad Al-Otaibi, Mohammed Hassan Ahmed, Ghaidaa Naser AbdulRazak, David Bakiratharajan, Talal Abdulla Alanzi and Tarek Essam Eldin Ahmed

Article Type: Case Report | First Published: August 29, 2022

Leiomyosarcomas (LMS) are rare tumors associated with poor outcomes. Treatment of the condition is challenging due to limited cases in the literature. Here, we present a case of a 46-year-old male who presented with left lower limb deep vein thrombosis, with an ultrasound scan revealing a right renal mass. MRI demonstrated a large, well-circumscribed lesion engulfing the middle and lower right renal poles associated with an invasion of the related part of the inferior vena cava (IVC), right rena...

 Open Access DOI:10.23937/2643-4563/1710044

Carcinoma Breast: Correlation of Immunohistohemical Expression of Cyclin D1 and Its Correlation with Clinicopathological Parameters in Indian Patients at Tertiary Care Hospital

Ritu Mehta and Rashmi Yadav

Article Type: Original Article | First Published: August 29, 2022

To study the prevalence of Cyclin D1 expression and its correlation with other clinicopathological parameters like age, tumor size, lymph node status, MBR grade, and expression of other immunohistochemical markers like ER, PR, Her 2 - neu, and Ki67. Thirty cases diagnosed were included in the study. All the cases were subjected to routine histopathology along with IHC for ER PR, Her2-neu, Ki67, and Cyclin D1....

 Open Access DOI:10.23937/2643-4563/1710043

Feasibility and Value of Salivary Cortisol Sampling to Reflect Distress in Head and Neck Cancer Patients Undergoing Chemoradiation: A Proof-of-Concept Study

Karishma Chhabria, MPH, PhD, Mark Bonnen, MD, Joshua Asper, PA-C, Giselle D Carnaby, MPH, PhD

Article Type: Systematic Review | First Published: September 12, 2022

Head and neck cancer (HNC) patients undergoing chemo/radiation commonly experience severe and persistent distress associated with treatment related fear and physical side effects such as xerostomia, dysphagia, and dryness of mouth. Cortisol, a stress sensitive hormone, can be easily measured in saliva to reflect biobehavioral responses to such stressors. Unfortunately, it has not been used in this population due to concerns associated with chemoradiation (C/RT) related xerostomia....

 Open Access DOI:10.23937/2643-4563/1710042

Breast Cancer in Men: A Systematic Review of the Literature from the Arab World

Pierre El Sett, Georges Jammal, Antoine El Sett, Ronaldo Elkaddoum, Hampig Raphael Kourie

Article Type: Systematic Review | First Published: July 29, 2022

Breast Cancer (BC) is the most frequent cancer worldwide accounting for 11.7% of all cancers but only for 1% of men’s cancers; therefore, men’s breast cancer is rarely discussed, especially in the Arab World. This review, the first of its kind in the region, aims at reporting current trends in the epidemiology of BC in men, based on studies from the Arab region....

 Open Access DOI:10.23937/2643-4563/1710041

Vulvar Biopsy as a Key for the Diagnosis of Langerhans Cell Histiocytosis with Multifocal Involvement: Case Report and Review of Literature

Sandra M Buitrago, Carolina Morante C, Laura Hernandez, Martha C Mendez

Article Type: Clinical Case | First Published: June 30, 2022

Langerhans cell histiocytosis is a rare disease and due to its heterogeneous presentation represents a diagnostic and therapeutic challenge. We present the case of a patient with diabetes insipid us and panhypopituitarism, with the appearance of painful vulvar ulcers. The vulvar biopsy confirmed Langerhans cell histiocytosis with spreading to multiple organs, so it was decided to start chemotherapy, achieving the complete elimination of all lesions....

 Open Access DOI:10.23937/2643-4563/1710040

Epidemiological Profile and Therapeutic Results of Brain Metastases after Encephalic Radiotherapy in Toto

M Zaouit, N Benchakroun, Z Bouchbika, H Jouhadi, N Tawfiq, S Sahraoui, and A Benider

Article Type: Abstract | First Published: June 30, 2022

Brain metastases are considered to be the most common malignant brain tumors in adults, and constitute a major challenge in oncology. The objective of our study is to analyze the epidemiological, clinical and paraclinical parameters of patients with brain metastases and treated by encephalic radiotherapy during the year 2020 at the Mohamed VI center of the Ibn Rochd CHU....

 Open Access DOI:10.23937/2643-4563/1710039

Surgery of Oncologic Surgical Pathologies during the COVID-19 Pandemic: The Ordeal of the Oncologic Patient

María Mercedes de la Torre-Bustamante, Juan Felipe Casabon-Pastrana, Diego Alejandro Largo- Cordoba, Diego Armando Gomajoa-Guerrero and Michael Gregorio Ortega-Sierra

Article Type: Editorial | First Published: March 24, 2022

The COVID-19 pandemic has been one of the worst global public health crises of the 21st century. Global health was strongly affected by the dynamics of nations in the face of measures to contain the SARS-Cov-2 infection, such as confinement and redistribution of resources, which delayed the diagnosis and treatment of a large number of diseases, negatively modifying the prognosis and quality of life of these patients. The burden of surgical and oncological diseases is currently very high, and its...

 Open Access DOI:10.23937/2643-4563/1710038

Prognostic Value of the Ki67 Proliferation Index, CD10 and MUM1 in Follicular Lymphoma

Minh Phuong Vu, Thanh Vui Le and Van Oanh Kieu

Article Type: Original Article | First Published: March 24, 2022

Follicular lymphoma (FL) is an indolent lymphoma and is associated with a long survival time. However, there are patients who had an early progression after standard therapy. Our aim was to analyze the prognostic value of Ki67, CD10 and MUM1 expression in FL. Immunohistochemical staining for Ki67, CD10 and MUM1 was performed on formalin-fixed paraffinembedded biopsy tissues from 27 patients with FL. Patients were grouped according to the levels of the Ki67 proliferation index (PI). Survival time...

 Open Access DOI:10.23937/2643-4563/1710037

Impacts of Genetic Polymorphisms on Breast Cancer

Hafez Ahmed and Mohamed Hussein

Article Type: Review Article | First Published: March 16, 2022

Breast cancer (BC), a malignant proliferation of the epithelial cells that line the ducts or lobules of the breast, is the most common malignancy in women, accounting for approximately one-third of all cancers in women worldwide. According to its death rate, it is the second most frequent cancer causing mortality for women worldwide. Polymorphism involves one of two or more variants of a particular DNA sequence. The most common type of polymorphism involves variation at a single base pair. In re...

 Open Access DOI:10.23937/2643-4563/1710034

Cell Proliferation, Contact Inhibition, and Apoptosis Profiling in a Benign and Malignant Breast Lesion

Olakayode V Ekundina, Chiamaka C Ejelue, Ondokeyi P Apulu and Ore-oluwa O Ayodele

Article Type: Original Article | First Published: January 29, 2022

Monitoring and diagnosis of benign or premalignant breast lesions as it progresses to a malignant condition is very necessary for its ability to predict or curb the progression of a breast lesion to the malignant condition and Immunohistochemistry has been proven to be a useful tool in achieving this as immunohistochemical markers are corresponding and specific in nature. The primary objective of this case-control study is to study the expression of KI67, E-cadherin, and P53 in normal breast tis...

 Open Access DOI:10.23937/2643-4563/1710036

Bladder Neuroendocrine Carcinoma: About Five Cases and Review of the Literature

Maryam Zaouit, Farida Marnissi, Hassan Jouhadi, Nadia Benchekroun, Asma Elkbir, Souha Sahraoui and Abdellatif Benider

Article Type: Case series | First Published: February 07, 2022

This is a retrospective descriptive study of five cases of neuroendocrine carcinoma of the bladder collected at the Mohammed VI Center, between January 2017 and December 2020. The diagnosis was confirmed by immunohistochemical study. The median age is 61 years (extremes: 36-73 years), all patients are male. The average delay of consultation is 7 months (extremes: 2-12 months). Chronic smoking was found in three patients. Hematuria was the cardinal sign in 4 cases. Irritative urinary disorders su...

 Open Access DOI:10.23937/2643-4563/1710035

Relationship between Awareness of Healthy Lifestyle and Perception of Breast Cancer among Women of Reproductive Age


Article Type: Original Article | First Published: January 31, 2022

The aim of this study was to determine the relationship between awareness of healthy lifestyle and breast cancer perception among women of reproductive age. This descriptive co relational study was conducted on 642 women. Data were collected using the sociodemographic data form, the Healthy Lifestyle Awareness Scale (HLAS), and the Breast Cancer Perception Scale (BCPS). A moderate, significant, and positive correlation was found between the HLAS total score and the scores obtained from the BCPS ...

 Open Access DOI:10.23937/2643-4563/1710033

Prognostic Utility of Targeted Circulating Cell-Free DNA versus Formalin-Fixed Paraffin-Embedded DNA Mutation Analysis for Advanced Lung Cancer

Madli Tamm, Mart Kals, Tarmo Annilo, Kersti Oselin, Katrin Keerma, Paula Ann Kivistik, Miriam Nurm, Margot Saare, Jana Jaal and Neeme Tõnisson

Article Type: Original Article | First Published: January 23, 2022

Cancer burden is a globally growing problem. Early diagnosis and targeted treatment decrease patients’ death rate, pain, and treatment expenses. Liquid biopsy can be used for early cancer detection, treatment selection, and progression and treatment response monitoring. We evaluated the performance of circulating cell-free DNA (cfDNA) and formalin-fixed paraffin-embedded (FFPE) tissue DNA analyses using a commonly employed targeted therapeutic pathway in predicting the outcomes of patients wit...

 Open Access DOI:10.23937/2643-4563/1710032

Nivolumab Induced Acute Pancreatitis and Hyperbilirubinemia

Unnati Bhatia, MD, Suryansh Bajaj, MD, Darshan Gandhi, MD, Divyansh Bajaj, MD

Article Type: Case Report | First Published: December 05, 2021

Immune checkpoint inhibitors (ICIs) are a novel treatment modality that is quickly becoming the standard of care for the management of a multitude of neoplasms. While immunomodulation is a promising approach, it also carries a risk of immune-related adverse effects (irAEs). Nivolumab is an FDA-approved anti-programmed death-1 (anti-PD-1) checkpoint inhibitor. Nivolumab-induced, immune-related pancreatitis, and hyperbilirubinemia are rare but clinically significant examples of irAEs. Early recogn...

 Open Access DOI:10.23937/2643-4563/1710031

Incidentally Found Thyroid Metastases in Head and Neck Squamous Cell Carcinoma - How to Manage It?

Gama R, Oliveira P, Teixeira M, Castro F and Condé A

Article Type: Original Article | First Published: September 10, 2021

The authors aim to review the available literature regarding incidentally found thyroid carcinoma during lymph node dissection for primary head and neck squamous cell carcinoma (SCC), in order to potentially support clinical decision about management of this unexpected entity. 2 clinical cases are described and a systematic review of the relevant literature on the subject is performed based on Pubmed® database. We reviewed a total of 102 cases. The primary SCCs sites were larynx, oral cavity, a...

 Open Access DOI:10.23937/2643-4563/1710030

Breast Metastases from Ovarian Primary: A Rare Entity and Review of Literature

Suresh Singh, Bhalgat Bhushan Sanjay, Pravin Kumar, Kamal Kishore Lakhera, Phanindra Kumar Swain and Raj Govind Sharma

Article Type: Case Report | First Published: July 24, 2021

Ovarian cancer is the fifth most frequent diagnosis of female malignancy and the second most common female gynecologic malignancy after breast cancer. The 5-year prevalence is 213 cases per million with 2.1 percent deaths as per GLOBOCON 2020 data. Clinical manifestations commonly include abdominal and pelvic pain with bloating, distention, urinary urgency and frequency, and unintended weight loss in the presence of tenderness to palpation and an adnexal mass on bimanual examination. Risk factor...

 Open Access DOI:10.23937/2643-4563/1710029

Epitope Spreading and the Efficacy of Immune Checkpoint Inhibition in Cancer

W. Robert Liu, PhD and David E. Fisher, MD, PhD

Article Type: Commentary | First Published: May 28, 2021

Therapeutic antibodies that target immune checkpoints have revolutionized cancer therapy. While these checkpoints restrain T cell activation in response to antigen engagement, checkpoint inhibitors de-repress such tumor-associated T cells, and have generated major clinical responses in multiple tumor types. Nonetheless, the vast majority of cancers remain resistant to this therapeutic approach as currently deployed, either through intrinsic or acquired resistance mechanisms. One key question inv...

 Open Access DOI:10.23937/2643-4563/1710028

On the Impact of Premature Termination of Chemotherapy on Relapse of Breast Cancer

Heidrun Männle, Karsten Münstedt, Felix Momm and Jan Willem Siebers

Article Type: Original Article | First Published: March 15, 2021

Some breast cancer patients receive a recommendation for adjuvant chemotherapy if necessary. In some cases, patients refuse this recommendation. In other cases, they start with chemotherapy, but then discontinue it. The question raised here are the effects of patients’ rejection or premature termination of recommended chemotherapies. 1916 patients, who received a recommendation for chemotherapy, were analyzed between 1997 and 2017. The analyses included descriptive analyses and Kaplan- Meier s...

 Open Access DOI:10.23937/2643-4563/1710027

Is there an Association between Vaginal Cancer and Genital Prolapse? A Data-Analysis and Review of Literature

Heidrun Männle, Birthe Osorio, Felix Momm and Karsten Münstedt

Article Type: Review Article | First Published: March 13, 2021

Primary vaginal cancer represents a rare disease. The main risk factor for vaginal carcinoma is a persistent human papillomavirus (HPV) infection. However, chronic mechanic irritation of the vagina, have long been suspected to contribute to the development of vaginal cancer. This study examined to assess possible associations between genital prolapse and the incidence of vaginal cancer. We conducted a systematic literature search regarding the association between vaginal cancer and genital prola...

 Open Access DOI:10.23937/2643-4563/1710026

Destructive Mono-Arthritis Caused by Mycobacterium bovis during Treatment with Pembrolizumab in a Patient Previously Treated with BCG Instillations for Bladder Cancer: A Case Report

Cynthia Epskamp, Susanne M Huijts, Peter AHM van der Lubbe and Debbie G.J. Robbrecht

Article Type: Original Article | First Published: February 10, 2021

Immune checkpoint inhibitor (ICI) treatment is an integral part of second line treatment of patients with urothelial carcinoma (UC) as well as in first line in cisplatin-ineligible patients with PD-L1 positive tumours. A substantial proportion of patients with bladder cancer have been treated with intravesical Mycobacterium bovis BCG in the past. Although it is rare, disseminated infections with Mycobacterium bovis have been described, but not in association with ICI treatment. We herein report ...

 Open Access DOI:10.23937/2643-4563/1710025

Evaluation of Clinical and Pathological Features of Follicular Lymphoma - A Three Year Descriptive Study in a Regional Cancer Centre in Western India

Rukmini Bezbaruah and Biren Parikh

Article Type: Original Article | First Published: November 22, 2020

This was a retrospective study where cases of FL were collected from the department of Oncopathology, at a tertiary care centre over 3 years from January 2017 to December 2019. Statistical analysis was done using the Software Statistical Package for the Social Sciences (SPSS) Version 20. Age range was from 35 to 84 years. Out of 69 cases, 18 cases (26%) were grade I, 32 cases (46%) were grade II, and 19 cases (27%) were grade III. Ki67 showed significant correlation in case of grade, stage, FLIP...

 Open Access DOI:10.23937/2643-4563/1710024

Hepatosplenic Gamma Delta T-cell Lymphoma Presenting as Progressive Hepatosplenomegaly Highlighted during Pregnancy

Hussam Almasri, MD, Mahir Petkar, MBBS, MD, FRCPath, Abdulaziz Zafar, MBBS, MRCP, Mohammed Abuwahed, MBBS, Mohammad Altermanini, MBBCH, Rita Ahmad, MD and Mouhammad Sharaf Eldean, MD, FCAP

Article Type: Case Report | First Published: June 19, 2020

Hepatosplenic T-cell lymphoma (HSGDTL) is a rare variant of T-cell lymphoma with few reported cases in literature. It usually presents with hepatosplenomegaly and constitutional symptoms, primarily in young to middle aged patients. The prognosis is generally poor, with maximum reported survival periods of 2-3 years. There is a link to immunodeficiency and some biological treatments. Liver biopsy with flow cytometry is required to confirm the diagnosis....

 Open Access DOI:10.23937/2643-4563/1710022

Assessment of Quality of Life in Radically Treated Head & Neck Cancer Patients: A Cross Sectional Study

Shekhar Kumar Keshri, MBBS, DMRT, MD, Satyendra Narayan Sinha, MBBS, DNB and Mitali Dandekar Lall, MBBS, MS, DNB

Article Type: Original article | First Published: May 20, 2020

Head and neck cancers pose a significant healthcare burden in India and more than two third of these patients present in advance stage. Multimodality treatment is recommended and often has detrimental impact on quality of life. A cross-sectional study was conducted from February-May 2019 among radically treated 73 head and neck cancer patients attending OPD for follow up using EORTC QLQ-C30 and QLQ H&N-35 questionnaires in Hindi language....

 Open Access DOI:10.23937/2643-4563/1710020

Mucoepidermoid Carcinoma of the Parotid Gland in a Patient with Duchenne Muscular Dystrophy: A Case Report

Geun-Jeon Kim, MD, Dong-Hyun Lee, MD, Chul-Woo Yang, MD, PhD and Dong-Il Sun, MD, PhD

Article Type: Case Report | First Published: January 22, 2020

We report the co-occurrence of Duchenne muscular dystrophy (DMD) and mucoepidermoid carcinoma (MEC) of the parotid gland. A 33-year-old male presented with a parotid gland tumor of benign appearance. After surgery, the patient’s serum creatine kinase level exceeded 20,000 IU/L (normal, 50-200 IU/L); his potassium level was also high (7.2 mEq/L), as were his aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels. Genetic testing revealed the deletion of exons 10-...

 Open Access DOI:10.23937/2643-4563/1710019

Usefulness of P16 and KI67 Immunostaining in Cervical Smear Cytology in Guatemalan Women: A Cross-Sectional Study

Alberto Garcia, MD, PhD, Angel Velarde, MD, MSCE, Francisco Quereda, MD, PhD, Jaume Ordi, MD, PhD, Orlando Rodas, MD, PhD, Erick Soch, MD, H Arturo Morales, MD, Federico Nave and Carlos Lopez, MD

Article Type: Original Research | First Published: October 18, 2019

Conventional cytology is an economic method for screening abnormalities in cervical smears, but with implications in false positive and false negative as compared to better detection of transformed cells with the Dual staining P16/KI67 proteins in cervical smears, therefore, we evaluate the validity and reproducibility of cytology with double staining of P16 and KI67 as compared to conventional cytology in cervical smears. Participants were 210 Guatemalan women with abnormalities in conventional...

 Open Access DOI:10.23937/2643-4563/1710018

Immunotherapy with the Vaccine Based On the Canine Neurotropic Virus (CIMT-54) For the Treatment of Cancer

Hugo Ramiro Segura-Puello, Juan Sebastian Segura Charry, Diana Milena Munoz-Forero, Diana Lorena Nieto Mosquera and Andrea Catalina Villamil-Ballesteros

Article Type: Original Article | First Published: October 16, 2019

At Cancer Research Laboratory of Manuela Beltran University (UMB), research was carried out with the design and development of the CIMT-54 biological vaccine: A combination of oncotropic virus + amino acids as adjuvants, which act directly on the tumor cell, preventing the reproduction of metastases to other organs and preventing the attack on healthy cells of the organism. The results at preclinical level suggested that the CIMT-54 vaccine is not cytotoxic; and on the other hand, in the studies...

 Open Access DOI:10.23937/2643-4563/1710017

Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer

Yoshiaki Nagatani, Yoshinori Imamura, Tsutomu Nakamura, Kazuhiko Yamashita, Mamoru Okuno, Hiroyuki Yasui, Jun Hiraoka, Riho Niigata, Keiji Kono, Yasuko Hyogo, Hirotaka Suto, Kei Takenaka, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota and Hironobu Minami

Article Type: Original Article | First Published: September 16, 2019

Although oxaliplatin is one of the main anticancer agents used against colorectal cancer, data on the pharmacokinetics of oxaliplatin in patients on hemodialysis are limited. In this case study, we evaluated the pharmacokinetics and safety of oxaliplatin in a patient on hemodialysis treated for colon cancer. A 68-year-old Japanese woman receiving chronic hemodialysis was treated for metastatic colon cancer with modified FOLFOX6 plus bevacizumab every 2 weeks. Initial oxaliplatin dose was reduc...

 Open Access DOI:10.23937/2643-4563/1710016

Nimotuzumab in Advanced Cervical Cancer: Safety and Efficacy Profile

Raiza Ruiz Lorente, Sayly Alfonso, Yamilka Sanchez, Carmen Elena Viada, Ramon Ortiz, Mayelin Troche, Meylan Cepeda, Ana Rosa Vals, Leticia Cabrera, Annia Gorte, Delmis Maira Batista, Milagros Domenech, Jessica Garcia Viamontes, Conrado Ramos Mico and Mayra Ramos Suzarte

Article Type: Review Article | First Published: July 29, 2019

The EGF receptor is over expressed in tumors of epithelial origin and is associated with a poor prognosis of the disease. An Expanded Clinical Access Program was carried out, in which patients with cervical uterine cancer in advanced stages of the disease without another therapeutic alternative were treated with nimotuzumab, anti-epidermal growth factor receptor humanized monoclonal antibody to evaluate the safety and efficacy of this therapy. Seventy-five patients with confirmed histological di...

 Open Access DOI:10.23937/2643-4563/1710015

Impact of the Number of Dissected Axillary Lymph Nodes on Survival in Breast Cancer Patients

Emad Eldin Nabil, Ahmed M Maklad, Ashraf Elyamany, Emad Gomaa and Moamen M Ali

Article Type: Research Article | First Published: June 05, 2019

For patients with breast cancer, axillary dissection was a standard treatment, especially with patient with positive metastases in the sentinel nodes. For some patients axillary dissection might be over-treatment, including those who have had a mastectomy. Especially with the new trend of many radiation-therapy centers, provide radiation-therapy for any number of positive lymph nodes. The aim of our work is to evaluate the impact of number of dissected axillary Lymph Nodes (LN), on Overall Survi...

 Open Access DOI:10.23937/2643-4563/1710014

Atypical Presentation of Denny-Brown Syndrome: A Case Report and Review of Literature

Romeo V Porlas Jr, MD, Scott Riley K Ong, MD, Gerard Raimon Saranza, MD, FPNA and Jose Paciano B Reyes, MD, FPNA

Article Type: Case Report | First Published: June 01, 2019

Paraneoplastic subacute sensory Denny-Brown neuronopathy affects the peripheral nervous system and commonly associated with small cell lung carcinoma and with other tumor types in 14.4% of cases. Presented is a case of 23, female with progressive numbness of extremities and ataxia. Investigations showed diffuse sensory neuronopathy and elevated CSF IgG on CSF studies. Paraneoplastic autoantibodies revealed negative results yet imaging showed an anterior mediastinal mass, which turned B-c...

 Open Access DOI:10.23937/2643-4563/1710013

Prostatic Ductal Adenocarcinoma: An Unusual Subtype of Prostate Cancer

Dinesh Kumar, MBBS, MS and John Lobo, MD

Article Type: Case Report | First Published: May 25, 2019

Ductal adenocarcinoma of the prostate (DAP) is defined as malignant epithelial cells filling large prostatic acini ducts, with preservation of basal cells forming either solid or dense cribriform patterns or a loose cribriform or micropapillary pattern with either marked nuclear atypia (nuclear size six times normal or larger) or Nonfocal comedonecrosis. DAP is a rare variant of prostate cancer, and has poorly-identified clinical characteristics....

 Open Access DOI:10.23937/2643-4563/1710012

Hydropneumopericardium: Unusual Complication of Proton Radiotherapy

Nakamura Yasuhiro, MD

Article Type: Clinical Image | First Published: May 13, 2019

Hydropnemopericardium is a very rare condition, which arises from penetrating trauma or blunt chest injury, development secondary to procedures, fistulization from adjacent structures and pericardial infections. This patient was 60-year-old man with hepatocellular carcinoma (HCC) presented to outpatients clinic with stomach pain, fatigue and anorexia. The patient was afebrile but laboratory profile manifested an excessive inflammatory response and disseminated intravascular coagulation. We detec...

 Open Access DOI:10.23937/ijor-2017/1710011

Effect of Specific Music on Psychoneuroimmunological Responses

Abdul Waheed, David Kossor, William Collins and Amy Camie

Article Type: ORIGINAL ARTICLE | First Published: December 31, 2018

A pilot study was done to measure quantitative EEG (qEEG) brainwave frequencies and behavioral indices of five women undergoing chemotherapy treatment for cancer, before and after listening to specific music (The Magic Mirror-Inspired Reflections solo harp CD written, performed and recorded by Amy Camie) once a day for ten days. Following treatments, the EEG profile for all five participants improved and subjective reports from daily questionnaires confirmed a positive effect of the music....

 Open Access DOI:10.23937/ijor-2017/1710010

Absorbed Radiation Dose in the Thyroid Gland Following Regional Nodal Irradiation for Breast Cancer

Tahani Nageeti, Mohamed Mahfouz, Mazen Al Gaod and Reem Zatar

Article Type: Original Article | First Published: November 19, 2018

Radiation exposure to the thyroid gland is unavoidable in breast cancer (BC) radiotherapy (RT). This study was conducted to evaluate the impact of using different supraclavicular (SCV) field angles on the percentage volume of the dose absorbed by the thyroid relative to the maximum dose absorbed by the spinal cord. A total of 50 consecutive BC patients undergoing planning computed tomography (CT) were evaluated. The thyroid gland, spinal cord, and SCV nodal volumes were contoured on the planning...

 Open Access DOI:10.23937/ijor-2017/1710009

Pembrolizumab Monotherapy in Relapsed Hepatocellular Carcinoma Post Living Donor Liver Transplantation and Sorafenib

Fadi Nasr, Ahmad Al Ghoche, Saada Diab, Janah Maddah, Layal Mansour, Ali kassem and Abd El Karim Gheith

Article Type: Case Report | First Published: November 12, 2018

Despite of the high incidence of hepatocellular carcinoma (HCC), treatment strategies stays restrained. New treatment aspects remain a necessity to improve overall survival of patients. Here, we report for the first time a 2 years complete remission of hepatocellular carcinoma with pembrolizumab after failure of sorafenib and progression after liver transplantation. Immunotherapy became a field of interest in HCC for researchers and clinicians in order to establish new immunotherapy modalities t...

 Open Access DOI:10.23937/IJOR-2017/1710008

Organoids as Reliable Breast Cancer Study Models: An Update

Andrew Octavian Sasmita and Ying Pei Wong

Article Type: Review Article | First Published: October 06, 2018

Having been identified for centuries, breast cancer still remains one of the leading causes of death in women. Within the United States of America (USA) alone, it is estimated that over 60,000 women would have developed new cases of malignant breast cancer in 2017 alone; thus, calling an attention for the development of a reliable and effective breast cancer model for drug discovery to combat the disease or diagnostics to predict the progression of the disease. Current breast cancer models invol...

 Open Access DOI:10.23937/IJOR-2017/1710007

Economic Costs of Lung Cancer in China

Shaoyu Fan, Zhengzhong Mao, Anita H Lee and Teh-wei Hu

Article Type: Case Report | First Published: September 29, 2018

The estimated total national medical cost of treating lung cancer patients in China was 64.21 billion RMB (US$ 10.31 billion), about 2% of total medical costs in 2015. Total lung cancer costs in 2015 were 488.53 billion RMB (US$ 78.42 billion), about 75% of which can be attributed to mortality costs. Two-thirds of the lung cancer patients in the sample were either current or former smokers. The major economic costs of lung cancer among smokers are preventable. China has a relatively low cigarett...

 Open Access DOI:10.23937/ijor-2017/1710006

Clinico‐pathological Features and Outcome of Treatment of Saudi Patients with Oral Cavity Cancer: A Single Institutional Experience

Ashraf Farrag, Arif Shaukat, Muhammad Ali and Magdy Kandil

Article Type: Research Article | First Published: July 28, 2018

Oral cancer is the most common head and neck cancer (HNC). Its global incidence in 2015 was 410,000 cases with 146,000 deaths. In USA, 41,380 patients were diagnosed with HNC in 2013, and oral cavity cancers accounted for almost 30,000 of new cases. In Saudi Arabia, a total number of 211 oral cancer cases were reported in 2014, representing about 1.8% of the total cancer cases....

 Open Access DOI:10.23937/ijor-2017/1710005

Locoregional Breast Cancer Surgery: Is there a Role in the Presence of Metastatic Disease?

J Bisnath, R Ramkissoon and J Ali

Article Type: Case Report | First Published: June 11, 2018

Treatment of Stage Four Breast Cancer has traditionally excluded locoregional surgery, with the focus being on control of the distant disease. Much of what is applied in clinical practice is extrapolated from chemotherapy trials in the adjuvant setting, with taxanes and anthracyclines incorporated early on in the treatment course....

 Open Access DOI:10.23937/ijor-2017/1710004

Clinical Results of Radiotherapy for Locally Advanced Stage III Pancreatic Cancer: A Single Institutional Experience

Yoshiomi Hatayama, Masahiko Aoki, Hideo Kawaguchi, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Mitsuki Tanaka, Koji Ichise, Shuichi Ono and Yoshihiro Takai

Article Type: Original Article | First Published: March 31, 2018

Fifteen patients with locally advanced stage III pancreatic cancer underwent radiotherapy with or without concurrent chemotherapy between July 2006 and April 2014. We used 10 MV X-rays and multiple coplanar (two to four) fields. The number of fractions ranged between 20 and 28 with a fraction size of 1.8Gy. A total dose of 36-50.4Gy at the isocenter of the planning target volume (PTV) was administered to each patient. Fourteen patients received chemotherapy during radiotherapy. The cumulative su...

 Open Access DOI:10.23937/ijor-2017/1710003

Assessment of HER2 Expression in Breast Cancer Using Fluorescence-Emitting Phosphor-Integrated Dot Nanoparticles

Kazutaka Otsuji, Takeshi Sasaki, Keiichiro Tada, Masashi Fukayama and Yasuyuki Seto

Article Type: Original Article | First Published: February 26, 2018

A new immunohistochemistry (IHC) method using fluorescence-emitting phosphor-integrated dot (PID) nanoparticles as a fluorescent dye was developed to accurately detect proteins that are expressed by cancer cells. This technique localizes proteins and quantitates their levels of expression in cancer lesions, which facilitates objective analysis of protein levels. We used the PID nanoparticle assay to measure HER2 expression in formalin-fixed, paraffin-embedded (FFPE) samples from patients with pr...

 Open Access DOI:10.23937/ijor-2017/1710002

Secretory Carcinoma of the Breast: An Elusive Presentation of This Rare Pathology

Joseph Brandt, Jack Morgani, Alan Heimann and Edna Kapenhas

Article Type: Case Report | First Published: November 16, 2017

Since first being noted in the literature in 1966, Secretory Breast Carcinoma (SBC) continues to be better defined in terms of its clinical, histologic, and genetic features. However, its unique presentation can elude seasoned practitioners from making a clinical diagnosis....

 Open Access DOI:10.23937/ijor-2017/1710001

Exploring the Potential of Endoscopic Examinations using the Kyoto Scoring System for Risk Evaluation of Gastric Carcinoma in Patients with Gastritis

Yasuhiro Nakmaura and Uch Somary

Article Type: Review Article | First Published: November 01, 2017

Cambodia is considered to be endemic to chronic gastritis due to Helicobacter pylori (HP). Prevalence of HP is more than 70% inferred from the literature of neighboring countries. However, Cambodia, being a developing nation, doesn’t have enough resources for the screening of HP. On the other hand, after the Kyoto Global Consensus in 2015, risk evaluation of gastric carcinoma based on endoscopic findings with image-enhanced modalities and magnification allows diagnosis of gastritis with a high...


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ClinMed Journals Index Copernicus Values

Clinical Medical Image Library: 93.51

International Journal of Critical Care and Emergency Medicine: 92.83

International Journal of Sports and Exercise Medicine: 91.84

International Journal of Womens Health and Wellness: 91.79

Journal of Musculoskeletal Disorders and Treatment: 91.73

Journal of Geriatric Medicine and Gerontology: 91.55

Journal of Infectious Diseases and Epidemiology: 91.55

Clinical Medical Reviews and Case Reports: 91.40

International Archives of Nursing and Health Care: 90.87

International Journal of Ophthalmology and Clinical Research: 90.80

International Archives of Urology and Complications: 90.73

Journal of Clinical Nephrology and Renal Care: 90.33

Journal of Family Medicine and Disease Prevention: 89.99

Journal of Clinical Gastroenterology and Treatment: 89.54

Journal of Dermatology Research and Therapy: 89.34

International Journal of Clinical Cardiology: 89.24

International Journal of Radiology and Imaging Technology: 88.88

Obstetrics and Gynaecology Cases - Reviews: 88.42

International Journal of Blood Research and Disorders: 88.22

International Journal of Diabetes and Clinical Research: 87.97

New Issues


International Journal of Clinical Cardiology

ISSN: 2378-2951 | ICV: 89.24



Obstetrics and Gynaecology Cases - Reviews

ISSN: 2377-9004 | ICV: 88.42



Journal of Hypertension and Management

ISSN: 2474-3690 | ICV: 87.69



International Journal of Diabetes and Clinical Research

ISSN: 2377-3634 | ICV: 87.97



Journal of Infectious Diseases and Epidemiology

ISSN: 2474-3658 | ICV: 91.55