Journal of Dermatology Research and Therapy is an international open access journal that delivers a focused, peer-reviewed, valuable collection of cases in all disciplines of dermatology including but not limited to Allergy Testing, Cosmetic Dermatology, Cryosurgery, Dermatopathology, Hair Transplantation, Immunodermatology, Intralesional Treatment, Laser Therapy, Mohs Surgery, Pediatric Dermatology, Photodynamic Therapy, Phototherapy, Psoriasis, Skin Cancers, Skin Lesions, Sweating Disorders, Systemic Therapies, Teledermatology, Topical Therapies, Tumescent Liposuction, Vitiligo Surgery, etc. It acts as a source of information for professionals and researchers in all the aspects of skin disorders.
Journal of Dermatology Research and Therapy is to encourage the publication of new information by providing a platform for reporting unique and rare cases of dermatology, diagnosis, management and clinic-pathologic correlations. The journal considers all the latest advances in the form outstanding research articles, letters, reviews, cases, commentaries, etc. in all aspects of dermatological Science.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2469-5750/1510078
Nathasia and Sukmawati Tansil Tan
Article Type: Case Report | First Published: February 03, 2020
Toxic epidermal necrolysis (TEN) is a life-threatening drug reaction that requires immediate medical treatment. Mortality due to TEN cases is quite high until now and the main cause reported is multiple organ dysfunction syndrome. A 7-year-old child, was diagnosed TEN with 86% blistered skin, after receiving Metampiron. Given 20% albumin 50 ml from the first day treated until 20 days, also fluid resucitation, steroids, antibiotics, vitamin C, neurobion, paracetamol, antihistamines, oral hygiene,...
Open Access DOI:10.23937/2469-5750/1510077
Article Type: Original Article | First Published: January 04, 2020
There are tremendous amount of the overthe- counter (OTC) hair loss products available online and widely purchase all over the world by many consumers. We conducted this study to evaluate some popular and widely used OTC hair loss products that are introduced by famous online retailer websites. Most of hair loss products are natural products, vitamins, minerals, amino acids and proteins. The products found in the top sellers are different between the online retailers regarding their type, side, ...
Open Access DOI:10.23937/2469-5750/1510076
Article Type: Mini Review | First Published: December 30, 2019
Organ transplant recipients (OTR) have 100-fold increased risk for cutaneous squamous cell carcinoma (cSCC) compared to the general population. Modified immune surveillance mechanisms may contribute to the perceived differences in incidence, clinical behavior and increased aggressiveness of cSCC in OTR. It could also provide some insight into the pathogenesis of cSCC in various disorders characterized by low immunity such as HIV, hematological malignancies and immune-mediated inflammatory disord...
Open Access DOI:10.23937/2469-5750/1510075
Mario Valenti, Paola Facheris, Giulia Pavia, Alessandra Narcisi, Riccardo Borroni and Antonio Costanzo
Article Type: CASE SERIES | First Published: December 30, 2019
Psoriasis is a common inflammatory skin disease that is estimated to affect about 2-4% of the population, with rates varying across ethnic groups and geographical regions. Biotechnological (more commonly called biologic drugs) drugs have shown great results in treating severe forms of psoriasis. Biologic agents that specifically block the IL-17 pathway have shown promising results with regard to efficacy and safety. Specific IL-17 inhibitors are represented by Secukinumab and Ixekizumab, fully h...
Open Access DOI:10.23937/2469-5750/1510074
Mohammed Al Abadie, Farlin Asharaff and Dina Al Abadie
Article Type: Research Article | First Published: September 09, 2019
Rosacea is found in approximately 10% of the general population and is known to mainly affect people from 30 to 60 years of age. It is more prevalent in female population as opposed to male population (with the exception of phymatous rosacea where majority of affected patients are adult male). A 2012 study consisting of 60,042 patients in the United Kingdom identified that 61.5% of patients with rosacea was female. Further studies suggest that rosacea has a greater impact on quality of life of f...
Open Access DOI:10.23937/2469-5750/1510073
Medina Andrade Luis Angel, MD, Laura Guadalupe Medina Andrade, MD, Lizbeth Elisa Oropeza Lopez, MD, Andrea Marianne Rodriguez Valencia, MD, Haizel Valencia Romero, MD, Angel Adrian Moreno Pina, MD, Araceli Esteban Chaparro, MD, and Alberto Robles Mendez Hernandez, MD
Article Type: Review Article | First Published: July 31, 2019
Pityriasis versicolor is a superficial fungal infection of the skin, characterized by pigmentary changes secondary to the colonization of the stratum corneum by a lipophilic dimorphic fungus known as Malassezia sp. Of this genus, 7 species known as the causative agent of pityriasis versicolor, the most frequently isolated species is M. Globosa. This skin disease occurs worldwide but predominates in the tropical, warm, and humid climate. Malassezia sp classified as dimorphic fungi since it behave...
Open Access DOI:10.23937/2469-5750/1510072
A Lahrichi, F Hali, K Baline, F Marnissi and S Chiheb
Article Type: Case Report | First Published: May 17, 2019
An 18-year-old patient presented with lupoid papulonodular lesions in the face. The diagnosis of disseminated lupus of the face was retained after eliminating other diagnoses including sarcoidosis, syphilis and leprosy. An antibacillary treatment was started without improvement for 3 months with onset of lesions. A 0.5 mg/kg/day isotretinoin treatment was started with improvement of the lesions. Thereafter, the patient benefited from 6 sessions of injection of platelet-rich plasma (PRP) with sag...
Open Access DOI:10.23937/2469-5750/1510071
Robustelli Test Elisa, Ferreli Caterina, Brundu Maria Angela, Atzori Laura, Pilloni Luca and Rongioletti Franco
Article Type: Case Report | First Published: May 15, 2019
Fox-Fordyce disease (FFD) is an uncommon chronic inflammatory skin disease of the apocrine sweat glands that could be considered as a rare adverse event of laser hair removal. It is postulated that laser therapy could induce damage to the follicular infundibulum, resulting in epidermal detachment and altered keratinocytes maturation which led to keratin plugging. Here, we present a case of a post-pubertal woman who developed axillary itchy lesions with clinical and histological features compatib...
Open Access DOI:10.23937/2469-5750/1510070
Isabela de Lima Bocalon, Mayara Fernandes Veri Marques and Idiberto Jose Zotarelli Filho
Article Type: Research article | First Published: May 08, 2019
With aging, occurs a decrease in the number of melanocytes active enzymatically around 12.0% to 24.0% every ten years. As a treatment, stem cell therapy with adult stem cells has been the focus of many studies. Among adult stem cells, adipose-derived stem cells (ADSC) ubiquinone, known as coenzyme Q10 (CoQ10), is a lipid-soluble antioxidant. It is shown to reduce lipid peroxidation of low-density lipoprotein regenerates endogenous vitamin E and protects cells against oxidative stress induced by ...
Open Access DOI:10.23937/2469-5750/1510069
Ahmed Bouhamidi, Mohamed El Amraoui, Hicham Rafik, Mohammed Boui and Naoufal Hjira
Article Type: Research article | First Published: April 27, 2019
Dermatological manifestations are frequent and varied among chronic hemodialysis patients. The aim of this study is to determine the prevalence and characteristics of cutaneous abnormalities observed in hemodialysis patients. We led a transversal study, conducted at the Nephrology Department of the 5th Military Hospital in Guelmim, from March to May 2017, including 44 hemodialysis patients....
Open Access DOI:10.23937/2469-5750/1510068
Daoqun Chong, Gai Ge, Dongmei Li, Yang Yang, Rong Wang, and Dongmei Shi, MD, PhD
Article Type: CASE REPORT | First Published: March 14, 2019
Psoriasis is a chronic, recurrent inflammatory skin disease characterized by abnormal keratinocyte proliferation and vascular hyperplasia. Apatinib is a tyrosine kinase inhibitor which has been reported to be effective in some tumors thought to be associated with inhibition of the proliferation of endothelial cells by selectively inhibiting vascular endothelial growth factor receptor-2 (VEGFR-2). We present a 54-year-old patient with a 30-year history of psoriasis, who did not respond well to or...
Open Access DOI:10.23937/2469-5750/1510067
Frederick H Silver, Ruchit G Shah, Michael Richard and Dominick Benedetto
Article Type: ORIGINAL ARTICLE | First Published: March 08, 2019
Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar and a verrucous carcinoma, a squamous cell carcinoma subtype, non-invasively and non-destructively. The results suggest that epidermal thickening and increased keratin production occur in verrucous carcinoma and lead to increases in surface hills and valleys as well as subsequent inc...
Open Access DOI:10.23937/2469-5750/1510066
Maria del Carmen Pantin Gonzalez, Diego Malon Gimenez, Beatriz Losada Vila, Beatriz Anton Pascual, David Gutierrez Abad, Nadia Sanchez Banos and Cristina Sanchez Cendra
Article Type: CASE REPORT | First Published: February 28, 2019
Melanoma is the most aggressive skin cancer and its incidence continues to increase worldwide. Molecular targeted kinase inhibitors have improved survival and tumor response for those patients with BRAF mutant disease. We describe the case of a patient under treatment with BRAF and MEK inhibitors (BRAFi and MEKi) who presents cutaneous toxicity grade 3, as an adverse effect due to treatment....
Open Access DOI:10.23937/2469-5750/1510065
Niema Aqil, Aicha Nassiri, Salim Gallouj and Fatima Zahra Mernissi
Article Type: Original Article | First Published: January 28, 2019
Ungual manifestations occurring in patients with end stage renal failure are polymorphic and diverse. The aim of our study was to assess the prevalence and characteristics of different ungual manifestations in patients end stage renal failure. We led a transverse investigation of all patients with end stage renal failure followed in the department of nephrology of University Hospital Hassan II, during a period of three months from 01 August 2016 to 01 November 2016....
Open Access DOI:10.23937/2469-5750/1510064
Makoto Kondo and Keiichi Yamanaka
Article Type: Case Report | First Published: January 11, 2019
One of the symptoms of creeping disease in humans is the accidental occurrence of hookworm-related cutaneous larva migrans (HrCLM). It usually occurs following contact with soil, sand, and mud found on beaches in tropical countries. Skin eruptions, such as linear nodules, appear on the foot and lower extremities. Misdiagnosis and inefficient treatment for travelers have often been reported. Although the parasite species remained unidentified in our case, the characteristic skin eruption in combi...
Open Access DOI:10.23937/2469-5750/1510063
Meltem Turkmen, Bengu Gerceker Turk, Isıl Kilinc Karaarslan, Gulsen Kandiloglu and Fezal Ozdemir
Article Type: Original Article | First Published: January 10, 2019
A 22-year-old-woman admitted with linear brownish papules and plaques on the right side of the trunk. The lesions initially had appeared on the right mammary at the age of 2-months and disseminated regionally throughout the axilla. The patient was previously followed with the diagnosis of epidermal nevus by some other physicians. On dermatologic examination, red-brown hyperkeratotic linear and annular plaques with elevated borders extending from the right mammary to the right axilla along the Bl...
Open Access DOI:10.23937/2469-5750/1510062
Salma Salim, Jamila Bouhelab, Asmae Benzekri and Badredine Hassam
Article Type: Case Report | First Published: September 26, 2018
Seborrheic keratoses (SK) are very common benign epidermal tumors. Their pathogenesis has been detected already in 2006 and includes several aetiological factors. The participation of human papilloma virus (HPV) is being discussed. SK of the penis is extremely rare and may be misdiagnosed. Histopathology will help in the diagnosis. Seborrheic keratoses (SK) are very common benign epidermal tumors. Their pathogenesis has been detected already in 2006 and includes several aetiological factors. The...
Open Access DOI:10.23937/2469-5750/1510061
Julia de Souza Gomes, Marina Silva Rita, Joao Marcos da Cunha Altomare, Nadia Rezende Barbosa Raposo, Marcos Antonio Fernandes Brandao and Hudson Caetano Polonini
Article Type: RESEARCH ARTICLE | First Published: September 07, 2018
When hair is exposed to the sun there may occur protein degradation, which alters its physical appearance. Thus, beneficial hair adjuvants with addition of natural sunscreens are sought for cosmetics development. In this study, we developed hair conditioning products containing blueberry, raspberry, cranberry and resveratrol in different proportions, incorporated into TrichoCond®. In vitro photoprotection capacities of the products and cystine content of the hair samples after treatments were d...
Open Access DOI:10.23937/2469-5750/1510060
Youssef Zemmez, Jaouad El Azhari, Badreddine Hassam and Nadia Ismaili
Article Type: Case Report | First Published: August 23, 2018
T/NK-cell lymphoma of nasal-type was described in 1933 as a malignant medio-facial granuloma. The diagnosis of this rare condition is clinical and immunohistopathological. We report an original case of cutaneous T/NK lymphoma of the nasal type revealed by cutaneous ulcerations....
Open Access DOI:10.23937/2469-5750/1510059
Abdulhadi Jfri and Ali Alajmi
Article Type: Research Article | First Published: August 04, 2018
Keloids are benign fibroproliferative tumors that occur as a response to any kind of injury to the skin to susceptible individuals. Keloid tissue extends beyond the margins of the wound which distinguish it from hypertrophic lesions. Keloids tend to grow symptomless, but still can often cause pain or itching. They have a functional, aesthetic, or psychosocial impact on patients, as highlighted by quality-of-life studies....
Open Access DOI:10.23937/2469-5750/1510058
Kazuhiro Hasegawa, Hiroyuki Sakamaki, Masahiro Higuchi, Masaaki Suemitsu, Chieko Taguchi, Ko Ito, Miyuki Morikawa, Tadahiko Utsunomiya, Toshirou Kondoh and Kayo Kuyama
Article Type: Original Article | First Published: July 30, 2018
Definitive diagnosis of oral lichen planus (OLP) is important for planning treatment. The problems and difficulties of diagnosing OLP based on histopathological features were showing inter- and intra-observer variability. In terms of pathological diagnosis on OLP, microvascular appearance was not highly valued. Comparative histomorphometric analysis of intraepithelial papillary capillary loops (IPCLs) of OLP was performed to investigate the potential for use as diagnostic criteria....
Open Access DOI:10.23937/2469-5750/1510057
Christian A Albornoz, Jordan V Wang and Matthew Keller
Article Type: Case Report | First Published: July 04, 2018
Cutaneous sarcoidosis is a common presentation for patients with sarcoidosis. Rarely, patients can present with psoriasiform lesions mimicking chronic plaque psoriasis. Here, we present a case of psoriasiform sarcoidosis in a pregnant patient. Pregnancy represents a unique challenge to systemic treatments if topical management fails. Tumor necrosis factor alpha inhibitors warrant special consideration during pregnancy....
Open Access DOI:10.23937/2469-5750/1510056
Youssef Zemmez, Ahmed Bouhamidi, Salwa Belhabib, Rachid Frikh, Mohamed Boui and Naoufal Hjira
Article Type: Case Report | First Published: June 25, 2018
Leprosy or Hansen's disease is an infection by Mycobacterium leprae (M. leprae), whose prevalence has considerably decreased since the application of the new anti-leprosy strategies advocated since 1982 by the World Health Organization (WHO). However, in the endemic countries several cases of leprosy are reported annually. We report a clinical case of lepromatous leprosy revealed by disseminated maculopapular lesions simulating a Sweet syndrome highlighting the importance of knowing how to evoke...
Open Access DOI:10.23937/2469-5750/1510055
Misani M and de Fontaine S
Article Type: Case Report | First Published: June 08, 2018
Cutis laxa is a rare disorder of the connective tissue, characterized clinically by loose, pendulous and inelastic skin producing the appearance of premature aging. The histology is peculiar for loss of dermal elastic tissue. It may be inherited or acquired, both forms being generalized or localized. The acquired localized form is very uncommon and is usually preceded by inflammatory lesions....
Open Access DOI:10.23937/2469-5750/1510054
Chelsea Tagaqa, John DiGiovanni, and Suzanne Wolf
Article Type: Case Report | First Published: June 07, 2018
A 21-year-old active duty soldier presented with skin lesions distributed on his face, arms, and hands. Two weeks prior to presentation he characterizes the development of lower lip herpetic lesion. He was otherwise well. Three days prior to presentation he was given Valtrex 1000 mg BID. He describes expressing fluid from lesions located bilaterally on his mandibular surface....
Open Access DOI:10.23937/2469-5750/1510053
Stephen M Akers, Greg A Barretto, Panitan Yossuck, Autumn S Kiefer, Michelle L Mitchell and Kathryn S Moffett
Article Type: Case Study | First Published: May 30, 2018
Primary cutaneous aspergillosis (PCA) is one of several invasive fungal infections that have increased in incidence in the last four decades. We present a case of an extremely low birth weight infant born at 24 weeks gestation diagnosed with cutaneous aspergillosis, highlighting the risk factors and clinical findings associated with neonatal PCA. Additionally, we discuss use of serum galactomannan testing as well as combination amphotericin B and voriconazole therapy....
Open Access DOI:10.23937/2469-5750/1510052
Christian A Albornoz, Jordan V Wang and Sherry Yang
Article Type: Case Report | First Published: May 12, 2018
Lichen sclerosus et atrophicus is a chronic inflammatory skin disease that typically affects prepubertal girls and peri- or post-menopausal women in genital and perineal areas. In some cases, it can also manifest as extragenital lesions. Extragenital Blaschkoid lesions have infrequently been reported. Here, we report a case of extragenital Blaschkoid lichen sclerosus et atrophicus in a child....
Open Access DOI:10.23937/2469-5750/1510051
Soh Nishimoto, Yohei Sotsuka, Kenichiro Kawai, Hisako Ishise and Masao Kakibuchi
Article Type: Research Article | First Published: December 02, 2017
Visual diagnosis of skin tumors is one of the most important steps in dealing with them. Nowadays, artificial intelligence has been booming and technology of automated cognition by computer has been improved. One of the bottlenecks in building an efficient cognition system is providing adequate amount of data to base on....
Open Access DOI:10.23937/2469-5750/1510050
Zijian Gong, Yayin Sun, Yating Peng, Wei Lai, Qingfang Xu and Yue Zheng
Article Type: Case Report | First Published: November 03, 2017
Genital pustular psoriasis is a rare condition characterized by well-demarcated, clear erythematous, absence of the typical scaling which is apparent on non-genital psoriasis. We describe a 30-year-old man with pustular psoriasis limited only to the glans, he was successively misdiagnosed as balanitis, Reiter's syndrome, coinfection of genital herpes and treated with itraconazole, prednisone, valaciclovir respectively, but without control. Skin biopsy was performed, and histopathological examina...
Open Access DOI:10.23937/2469-5750/1510049
TK Pandian, Vikram Krishnamurthy and Tina J Hieken
Article Type: Research Article | First Published: October 18, 2017
The incidence of and death rate from Cutaneous Melanoma (CMM) continue to increase. Prior data suggests that more than half of CMM are detected by patients or their close contacts and that this Patient-Detected Melanomas (PDM) present at higher stage than those found by physicians....
Open Access DOI:10.23937/2469-5750/1510048
Hiroshi Maruta, Pham-Thi Be-Tu and Mok-Ryeon Ahn
Article Type: Mini Review | First Published: September 04, 2017
A natural sleeping pill and 'elixir' (longevity-promoter) called 'Melatonin' is one of the first natural anti-melanogenic compounds, and originally derived from bovine pineal glands. However, currently the majority of melatonin product in the market is chemically synthesized. Since then a wide variety of anti-melanogenic compounds such as curcumin, CAPE (Caffeic Acid Phenethyl Ester), and Artepillin C (ARC) were identified in nature as well as chemically synthesized compounds such as Gleevec....
Open Access DOI:10.23937/2469-5750/1510047
Hoon Hur, Chan Hyuk Park, Yu Ri Kim and Dong Nyeok Hyun
Article Type: Case Report | First Published: August 17, 2017
Ota's nevus is a congenital benign oculodermal melanocytosis as a macular hyperpigmentation on the face. The color of lesion is mostly blotchy gray to blue or blue. Ota's nevus can cause emotional and psychological distress because the face can be a disfigurement, so appropriate treatment is necessary....
Open Access DOI:10.23937/2469-5750/1510046
Zhong-Shuai Wang and Jun Li
Article Type: Review Article | First Published: July 08, 2017
Paraneoplastic Pemphigus (PNP) is an autoimmune-related acquired bullous disease associated with neoplasia. Both humoral and cellular immunity are involved in the pathogenesis of PNP. Characteristically, PNP has a diverse spectrum of clinical and immunopathological features....
Open Access DOI:10.23937/2469-5750/1510045
Omer Sager, Hakan Gamsiz, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal and Murat Beyzadeoglu
Article Type: Review Article | First Published: June 12, 2017
Apart from systemic or nodal lymphomas, cutaneous lymphomas present a heterogeneous group of relatively infrequent non-Hodgkin lymphomas with distinct clinical characteristics. Among cutaneous lymphomas, primary cutaneous T cell lymphomas account for the majority of cases with Mycosis Fungoides (MF) being the most prevalent subtype....
Open Access DOI:10.23937/2469-5750/1510044
Madalene CY Heng
Article Type: Case Report | First Published: March 20, 2017
Ultraviolet light-induced damage to the DNA resulting in double-stranded triggers the DNA Damage Response (DDR). This results in Cell Cycle Arrest (CCA) and Nucleotide Excision and Repair (NER) of the photo-damaged DNA. These processes are regulated by a family of phosphatidylinositol-3-kinase family....
Open Access DOI:10.23937/2469-5750/1510043
Xiaoyue Wang, Pengfei Song and Jing Wang
Article Type: Case Report | First Published: February 25, 2017
Linear IgA bullous dermatosis (LABD) is a rare auto-immune bullous disease occurring in adults or childhood. There are similarities and differences between these two subtypes of the disease. We report a twenty-seven-year-old patient with adult subtype of LABD. The disease started from the second month of gestation and remitted after the delivery....
Open Access DOI:10.23937/2469-5750/1510042
Perruchoud DL, Kiermeir DM, Adatto MA, Lam MC, Borradori L and Simon D
Article Type: Case Report | First Published: February 18, 2017
Tattoo reactions are most commonly associated with red inkdue to the presence of mercury and its sulphides. However, nowadays most allergic reactions to red tattoo are triggered by organic pigments such as Pigment Red 181 (CI 73360) and Pigment Red 170 rather than the traditional mercury sulphides. The use of red pigments containing mercury may result in lichenoid reactions and other localized side reactions....
Open Access DOI:10.23937/2469-5750/1510041
Ben Salah Raida, Cherif Yosra, Frikha Faten, Snoussi Mouna, Jallouli Moez, Marzouk Sameh and Bahloul Zouhir
Article Type: Case Report | First Published: December 17, 2016
Some case reports and series presumed a link between malignancy and relapsing polychondritis. The most frequent described neoplasms have been hematological disorders especially myelodysplastic syndromes. Less commonly have also been reported solid neoplasms as colorectal cancer like our patient. We suggest that patients with RP should be monitored more carefully even in remission for early detection of cancer....
Open Access DOI:10.23937/2469-5750/1510040
Neeraj Singh, Britta Sundquist and Prashant Kaushik
Article Type: Case Report | First Published: December 14, 2016
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign condition featuring nodular or papular lesions of the dermis, subcutaneous tissue, and adjacent lymph nodes, commonly affecting the head and neck. The etiology is unknown, but case reports have thus far demonstrated an idiopathic origin. We describe here a case of ALHE occurring as an adverse effect of anti-tumor necrosis factor-alpha (TNF-α) inhibitor use, which has not previously been reported. An 81-year-old man with a ...
Open Access DOI:10.23937/2469-5750/1510039
Article Type: Mini Review | First Published: November 30, 2016
Dermatitis herpetiformis (DH) is an autoimmune bullous disease characterized by intensely pruritic, chronic, and recurrent vesicles on extensor surfaces such as the elbows, knees, and buttocks. The collection of neutrophils at the papillary tips is the typical histopathological finding, and a characteristic diagnostic feature is granular immunoglobulin A deposition in the papillary dermis by direct immunofluorescence....
Open Access DOI:10.23937/2469-5750/1510038
Marius A Kemler
Article Type: Original Article | First Published: November 23, 2016
Skin cancer frequently occurs at or around the tip of the nose. Repair of small surface defects after resection of skin cancer therefore form an everyday problem to the plastic surgeon. The nose has a number of characteristics that make it unique when planning for reconstruction of surgical defects. The skin over the lower third of the nose has limited mobility and, therefore, cannot be easily recruited for closure of anything but small defects....
Open Access DOI:10.23937/2469-5750/1510037
A Single-Site, Investigator Initiated Open-Label Trial of H.P. Acthar® Gel (Repository Corticotropin Injection) an Adrenocorticotropic Hormone (ACTH) Analogue in Subjects with Moderately to Severely Active Psoriatic Arthritis (PsA)
Justus J Fiechtner, Tresa Montroy and Joshua June
Article Type: Original Article | First Published: October 26, 2016
Although several therapeutic agents are available for psoriatic arthritis (PsA), each has limitations. Acthar® Gel (repository corticotropin injection) is FDA-approved for treatment of acute episodes or exacerbation of PsA, but no clinical trials have investigated it for those uses. This 28-week, prospective, single-center, open-label trial included subjects with moderately to severely active PsA. The primary outcome measure was ACR20 at Week 12....
Open Access DOI:10.23937/2469-5750/1510036
Maria Jose Alves de Oliveira, Regina Maia, Lucia Almeida Braz, Ademar Benevolo Lugao, Valdir Sabbaga Amato and Duclerc Fernandes Parra
Article Type: Original Article | First Published: October 24, 2016
Biomaterials comprise a scientific field where synthetic materials are developed for pertinent biological functions, yielding a wide diversity of new products. Although widely employed, they still require improvement for therapeutic purposes. The objective of this study was to develop poly (N-2-vinyl-pyrrolidone) (PVP), poly (vinyl alcohol) (PVAl), clay, and N-methyl glucamine hydrogels for the treatment of cutaneous leishmaniasis. The characterization techniques used were tumescence, energy-dis...
Open Access DOI:10.23937/2469-5750/1510035
Yang-lin Hua, Wei Gao, Hong-ying Li and Jian Tang
Article Type: Mini Review | First Published: October 14, 2016
Skin is the external organ of human body that provides protection against environmental stress. Direct and indirect damage causes skin aging. Scientists have been struggling to explore the mechanisms of skin aging and to think of ways to delay this course. The role of mast cell in regulating skin aging has attracted much attention recently. The granules of mast cell contain a great diversity of highly toxic compounds and active mediators. Degranulation of mast cell in papillary dermis may lead t...
Open Access DOI:10.23937/2469-5750/1510034
Maria J Haye Salinas, Veronica Saurit, Alejandro Alvarellos, Francisco Caeiro, Daniel Wojdyla, Cristina Drenkard, Guillermo J Pons-Estel, Luis J Catoggio, Judith Sarano, Eduardo Ferreira Borba, Emilia Sato, Sergio Jacobelli, Luis A Ramirez, Marlene Guibert -Toledano, Virginia Pascual-Ramos, Mario H Cardiel, Maria I Segami, Isaac Abadi, Graciela S Alarcon, Bernardo A Pons-Estel and Latin American Study Group on Lupus (GLADEL)
Article Type: Original Research | First Published: October 12, 2016
SLE patients from 34 centers in nine Latin American countries with a recent diagnosis (≤ 2 years) were studied. Socioeconomic-demographic characteristics and clinical features according to the presence of cutaneous manifestations were examined by univariable and multivariable logistic regression analyses. Their predictive value for the occurrence of other clinical manifestations was also examined....
Open Access DOI:10.23937/2469-5750/1510033
Jeong Rae Yoo, Miyeon Kim, Keun Hwa Lee, Seung Jin Yoo, Chang lim Hyun, Jonghwan Bae, Sang Taek Heo and Yong-Geun Park
Article Type: Case Report | First Published: October 05, 2016
A 53-year-old man with a history of poliomyelitis underwent left total hip arthroplasty in December 2011. His past medical history was not significant except the medical conditions described disease. The patient had developed a sore on right perianal area since March 2013 (Figure 1A), and infected sore lesion was extended to abscess on a right buttock abscess one year later, it was managed with incision and drainage in right buttock abscess since November 2014. ...
Open Access DOI:10.23937/2469-5750/1510032
Camila S Oliveira, Ana Beatriz PP Silva, Leopoldina L Fagundes, Nadia RB Raposo, Anderson O Ferreira, Marcos Antonio F Brandao and Hudson C Polonini
Article Type: Research Article | First Published: August 31, 2016
Oily skin presents shine in excess, as well as increased pores and acne. For this reason, people with oily skin have more difficulty using cosmetics in general. This is the first report in literature to evaluate amulti-purpose dermatological emulsion containing Melaleuca alternifolia Cheel (Myrtaceae) (tea tree) oil and resveratrol for oily skin....
Open Access DOI:10.23937/2469-5750/1510031
Tugba Falay, Vefa Asli Erdemir, Sevil Savas, Mehmet Salih Gurel and Ezgi Ozkur
Article Type: Case Report | First Published: August 29, 2016
Fluoroscopy induced chronic radiation dermatitis (FICRD) is a rare complication which can be difficult to diagnose and treat. Recently fluoroscopy use has increased and the diagnostic and the theuropathic fluoroscopy procedures are becoming more complex; therefore incidence of FICRD is rising. Because of presentation often occurs after months or years patients are sometimes unaware of exposure to radiation....
Open Access DOI:10.23937/2469-5750/1510030
Hanane Rachadi, Nadia Ismaili and Badreddine Hassam
Article Type: Case Report | First Published: July 20, 2016
We report a case of subintrant push of erythema nodosum caused by the Imatinib (Glivec) administration in a patient aged of 34 years old and followed for chronic myeloid leukemia. The drug provocation test was positive. In front of the recurrent, the painful character, the significant functional deficiency caused by the lesions and the positive drug provocation test, the imatinib was finally stopped. The evolution was characterized by the absence of recurrence 2 years after stopping the treatmen...
Open Access DOI:10.23937/2469-5750/1510029
Shawn L Shah, Joan Paul, Alicia T Dagrosa, Erik Jenson, Zilla Hussain, Stuart Gordon and Michael Shane Chapman
Article Type: Case Report | First Published: July 18, 2016
Esophagitis dissecans superficialis (EDS) is a rare endoscopic finding characterized by sloughing of the esophageal mucosal lining, which has been infrequently associated with autoimmune bullous dermatoses. We report a case of a 77-year-old man who presented with diffuse mucocutaneous bullous lesions and odynophagia. Direct immunofluorescence of a skin biopsy confirmed a diagnosis of bullous pemphigoid and esophagogastroduodenoscopy revealed linear fissures and sloughing of the esophageal mucosa...
Open Access DOI:10.23937/2469-5750/1510028
Shuk-Fan Tong, Joanne Yip, Kit-Lun Yick and Marcus Chun-Wah Yuen
Article Type: Case Report | First Published: June 30, 2016
Pressure ulcers are a frequent occurrence in the bedridden elderly, especially those who are over 65 years old. The healing of pressure ulcers is particularly difficult for these individuals as most of them may have different kinds of chronic illnesses and a low metabolism. Also, the healing process is complicated as there are numerous extrinsic and intrinsic contributing factors that influence the development and healing of pressure ulcers. Therefore, in this study, the healing progress of an e...
Open Access DOI:10.23937/2469-5750/1510027
Jimenez-Garcia Victoria Alejandra, Silla-Prosper Maria Magdalena, Arguelles-Arias Federico, Caunedo-Alvarez Angel, Moreno-Ramirez David and Herrerias-Gutierrez Juan Manuel
Article Type: Case Report | First Published: June 04, 2016
An increase of risk of malignancies such as lymphoma and non-melanoma skin cancer has been reported with the chronic use of immunomodulators in inflammatory bowel disease, particularly thiopurines. A case of a patient with ulcerative colitis after several years in immunosuppressive therapy developing multiple non-melanocytic skin neoplasms is described below....
Open Access DOI:10.23937/2469-5750/1510026
Jose D Cordoba and Erwin E Argueta
Article Type: Review Article | First Published: May 04, 2016
Rosacea and Parkinson's disease (PD) are two completely different pathologies, with different outcomes, that share a common interesting feature as their proposed originating factor. Both conditions show inflammation as a pre-dominant aspect of their pathogenesis, having an important role in the excessive breakdown of connective tissue components. Metalloproteinases (MMPs) and Toll-like receptors (TLRs) are present in the skin and brain in physio-logical conditions, but can be significantly up re...
Open Access DOI:10.23937/2469-5750/1510025
Khodayar-Pardo Parisa, Sanchez Mari Maria and Lopez Garcia M Jose
Article Type: Short Note | First Published: May 02, 2016
The diaper rash is a common medical query in pediatric offices. Most of the time it is due to a contact dermatitis or mild infection that only requires local care for its resolution. The appearance of more severe lesions, such as ulcers, and the resistance to conventional therapy should make us suspect the existence of an underlying disease....
Open Access DOI:10.23937/2469-5750/1510024
David M. Kleinman
Article Type: Short Review | First Published: April 21, 2016
It is very likely that dermatologists will see patients who have both skin concerns and concomitant dry eye syndrome. Over 25 million Americans have some form of dry eye, and symptoms related to dry eye are one of the leading causes of visits to ophthalmologists. Dry eye syndrome can often be easy to diagnose, and the first line of interventions are simple, low risk, and low cost. Specialists and subspecialists are generally averse to making medical recommendations outside their field of experti...
Open Access DOI:10.23937/2469-5750/1510023
Jing Gao and Anjali Mahto
Article Type: Review Article | First Published: April 20, 2016
Acne vulgaris is a multifactorial disease of the pilosebaceous unit as a result of androgen-induced increased sebum production, altered keratinisation, inflammation, and hair follicle bacterial colonisation by Propionibacterium acnes (P. acnes). The clinical features of acne include seborrhea, comedones, and papules and pustules. Nodules and cysts are seen in severe nodulocystic acne and scarring can follow. Acne can occur alone or with signs of hyperandrogenism such as hirsutism, alopecia and m...
Open Access DOI:10.23937/2469-5750/1510022
V Vergote, P Wolter, E Hauben and AM Busschots
Article Type: Case Report | First Published: April 13, 2016
Ten patients (8 male, 2 female) with a median age at diagnosis of 45 years were included. The median duration of the presence of skin lesions before diagnosis was 11 years. The most common sites of involvement were head and neck (80%), trunk and extremities (80-90%). Clinical features included patches and plaques, often associated with follicular prominence and alopecia, or comedo-like lesions, nodules and cysts. Fifty percent complained of pruritus. Histological findings included folliculotropi...
Open Access DOI:10.23937/2469-5750/1510021
Gokce Isil Kurmus, Filiz Canpolat, Muzeyyen Gonul and Murat Alper
Article Type: Case Report | First Published: April 12, 2016
Follicular mucinosis (FM), also known as alopecia mucinosa, is a rare inflammatory disorder that characteristically presents as follicular papules or infiltrated plaques with prominent follicular openings associated with alopecia. Histologically, the disorder is characterized by mucin deposition in the follicular epithelium and sebaceous glands. FM was classified in two distinct entities: a primary or idiopathic form, usually presents in children and young adults with a benign course, and a seco...
Open Access DOI:10.23937/2469-5750/1510020
Pinar Ozuguz, Seval Dogruk Kaca and Serap Polat
Article Type: Review Article | First Published: April 11, 2016
Melanoma is a highly aggressive tumour with poor prognosis in the metastatic stage that arises and evolves due to a myriad of genetic and epigenetic events. Among these, the interaction between epigenetic alterations (i.e., DNA methylation, histone modifications, mRNA silencing by miRNAs and nucleosome repositioning) has been recently identified as playing an important role in melanoma development and progression by affecting key cellular pathways such as cell cycle regulation, DNA repair, apopt...
Open Access DOI:10.23937/2469-5750/1510019
Marcella Gabrielle Mendes Machado, Paulo Renato Yamasaki, Jean Leandro dos Santos and Chung Man Chin
Article Type: Short Review | First Published: April 04, 2016
Malignant melanoma is a serious health problem once the current chemotherapy exhibits resistance to traditional drugs. Several challenges must be overcome during drug design in order to increase the efficacy and safety of the new drugs. Therefore, the specific chemical release of cytotoxic agents near to the target is an attractive approach to improve the anticancer activity and reduce the systemic toxicity. Herein, this review article describes the advances in the development of targeted prodru...
Open Access DOI:10.23937/2469-5750/1510018
Stephanie Chapman, Daniel Delgadillo and David T. Rispler
Article Type: Short Review | First Published: March 09, 2016
Pyoderma gangrenosum (PG) is an uncommon disease characterized by necrotic ulcers that are often associated with underlying systemic disease. PG can occur at the surgical site following surgery, including orthopedic surgery, and may be commonly mistaken for postoperative infection, delaying diagnosis and resulting in wound deterioration and subsequent sequelae. Previously, 20 case reports of PG have been reported after orthopedic surgery. We reviewed these cases and found the majority (60%) were...
Open Access DOI:10.23937/2469-5750/1510017
Zaid Hindi, Michael Sidiropoulos, Ayman Al Habeeb, Danny Ghazarian, Niloufar Hosseini and Kenneth J. Craddock
Article Type: Original Research | First Published: February 29, 2016
Multicolour FISH was performed using a commercially available probeset (Abbott Laboratories, Abbott Park, IL), on formalin-fixed, paraffin-embedded tissue samples from 40 tumours: 20 benign melanocytic nevi, and 20 metastatic melanomas within lymph nodes, as determined by histologic assessment. Fluorescent signals for each probe were enumerated by 2 observers in 30 cells each per lesion....
Open Access DOI:10.23937/2469-5750/1510016
Hussein Ghanem and Heba Darwish
Article Type: Review Article | First Published: February 29, 2016
Different approaches have been described for botulinum toxin (BTX-A) injections for face rejuvenation. Most techniques are based on the experience of the injecting physician and his/her learning curve. We describe a simplified approach to achieve accurate reproducible symmetric results with physicians of variable experience levels....
Open Access DOI:10.23937/2469-5750/1510015
Paul Ting-Yuan Cheng, Lissa Elaine Judd and Agneta Carol Fullarton
Article Type: Review Article | First Published: February 29, 2016
Erosive pustular dermatosis (EPD) is a cutaneous inflammatory condition, characterized by chronically non-healing lesions with sterile pustules and hyperkeratotic crusted erosions. Although rare, severe cases have been referred by dermatologists to plastic surgeons for management. The aim of this paper was to describe the presentation and management of extensive EPD as well as a review of current literature on this rare condition....
Open Access DOI:10.23937/2469-5750/1510014
Christoph Wallner, Marcus Lehnhardt and Bjorn Behr
Article Type: Short Review | First Published: February 17, 2016
Myostatin is a protein well described for its role in decelerating muscle anabolism. Most studies targeting the Myostatin pathway were performed in muscle wasting diseases. Recent studies unveil a potential approach to interfere with the Myostatin pathway to facilitate wound healing. We therefore reviewed the present literature for aiming the Myostatin pathway as a potential treatment option in impaired skin healing. The inhibition of Myostatin may facilitate wound healing through different ways...
Open Access DOI:10.23937/2469-5750/1510013
Kate V. Viola, Kameron S. Rezzadeh, Daniel G. Federman, Christine J. Mathew, Shasa Hu, Andrea D. Maderal, Steven R. Cohen and Robert S. Kirsner
Article Type: Research Article | First Published: January 16, 2016
Over 3 million skin cancers are diagnosed in the United States each year. While the incidence of skin cancer is lower in patients of Hispanic descent, a recent report by the Center for Disease Control (CDC) found melanoma incidence rates to be significantly higher in Hispanic women under the age of 50 as compared to Hispanic men; Hispanics had the highest incidence of acral lentigenous melanoma among all races and ethnicities....
Open Access DOI:10.23937/2469-5750/1510012
Jong-Seob Park, Ji-Sun Hong and Sang-Moon Han
Article Type: Case Report | First Published: January 16, 2016
Severe obesity is commonly associated with dermatologic disorders such as intertrigo, psoriasis and hidradenitis suppurativa (HS). HS is a chronic inflammatory skin disease characterized by clusters of nodules, cysts, and abscesses that commonly affects hair bearing areas such as axilla, groin and perianal regions. Treatments of HS are complicated and vary depending on presentation and severity of the disease. We report here, the case of a 36-year-old female who showed rapid improvement of long-...
Open Access DOI:10.23937/2469-5750/1510011
Hyeree Kim, Hei Sung Kim, Sang Hyun Cho and Jeong Deuk Lee
Article Type: Case Letter | First Published: December 01, 2015
Morphea, Bullous morphea, Hemorrhagic bullous morphea, Hemmorrhagicmorhea, Localized scleroderma, Bullous localized scleroderma. Bullous morphea is a rare form of localized scleroderma (morphea) characterized by bullae on or around an atrophic morphea plaque. The cause of bullae formation in morphea is multifactorial, with lymphatic obstruction from the sclerodermatous process being considered as the most likely cause....
Open Access DOI:10.23937/2469-5750/1510010
Hyeree Kim, Sang Hyun Cho, Jeong Deuk Lee and Hei Sung Kim
Article Type: Case Letter | First Published: November 30, 2015
A 31 year-old Korean woman presented with an asymptomatic, solitary, 0.5 cm-sized, skin-colored, firm, immovable mass on the antitragus of the left ear for one year (Figure 1A). She denied of previous trauma or infection. We initially suspected the mass as a dermatofibroma or nevus, because of its clinical manifestation. We performed a skin biopsy for confirmative diagnosis....
Open Access DOI:10.23937/2469-5750/1510009
Leslie K Dennis, Stephanie G Lashway and Marvin E Langston
Article Type: Research Article | First Published: November 16, 2015
Few studies have examined sun sensitivity risk factors for cutaneous melanoma specifically in populations of Spanish descent. Previous searches were conducted in PUBMED for articles on melanoma and sun exposure through 2008. Over 300 articles were reviewed and relevant data was abstracted. These abstract forms were subsequently reviewed for studies in populations of Spanish descent. PUBMED was then examined for more recent studies of melanoma in populations of Spanish descent. Eight appropriate ...
Open Access DOI:10.23937/2469-5750/1510008
Pinar Ozuguz, Seval Dogruk Kacar, Ozlem Ekiz and Semsettin Karaca
Article Type: Research Article | First Published: September 21, 2015
Telogen effluvium (TE) is a hair disorder characterized by abrupt onset, diffuse, self-limited and excessive shedding of club hairs. The purpose of this study was to investigate serum zinc, vitamin B12 and folic acid levels as well as parameters of iron metabolism and thyroid functions in patients with chronic telogen effluvium (CTE) and compare the results to those of the controls. Methods: In this study, a total of 260 patients with CTE who were admitted to the outpatient dermatology clinic of...
Open Access DOI:10.23937/2469-5750/1510007
Loan Towersey, Maria Victoria Quaresma, Fred Bernardes Filho, Porphirio Jose Soares Filho, Ines K. Praxedes Baeta Neves, Andrea Rodriguez Cordovil Pires, Omar Lupi and Roderick Hay
Article Type: Correspondence | First Published: September 05, 2015
Jessner's lymphocytic infiltration of the skin (JLIS) is a skin condition of unknown an etiology characterized by erythematouspapules, plaques, and/or nodules located on the head, neck and upper back. Lesions usually are asymptomatic and resolve without scarring. JLIS can be similar in appearance to other benign lymphocytic infiltrates which include for instance a variant of lupus erythematosus (LE), in particular, tumid LE....
Open Access DOI:10.23937/2469-5750/1510006
Theodora A Koulis, Colleen Herring, Wendy Smith and Jon-Paul Voroney
Article Type: Case Report | First Published: September 02, 2015
A patient with a severe form of Epidermolysis Bullosa (EB) presented after an above knee amputation and groin dissection for a 57 cm Squamous Cell Sarcinoma (SCC) of the skin and underlying soft tissue of the right leg. Five of 19 nodes were involved with SCC metastases. Standard care would involve adjuvant Radiation Therapy (RT) but RT has historically been avoided in patients with EB who can have severe, non-healing cutaneous and mucosal morbidity from acute RT reactions. A radiation treatment...
Open Access DOI:10.23937/2469-5750/1510005
Vikas Patel, Stephen Squires, Tarek Shaath, Daniel R Hinthorn, Garth R Fraga and Rebecca Horvat
Article Type: Case Report | First Published: August 20, 2015
Mucormycosis is a potentially fatal systemic fungal infection. Risk factors include immunosuppression, organ transplantation, and diabetes mellitus. Rhinocerebral mucormycosis is the most common presentation in diabetic patients, whereas pulmonary mucormycosis is the most common presentation in patients with hematologic neoplasms. We describe an immunocompromised leukemia patient with painful ecchymotic plaques on the forearm. Punch biopsy demonstrated angioinvasive mucormycosis and culture grew...
Open Access DOI:10.23937/2469-5750/1510004
Justin G. Hastings, Alok Vij and Anthony P. Fernandez
Article Type: Case Report | First Published: August 15, 2015
Vancomycin therapy is associated with several hypersensitivity reactions, the most common being the non-immunologically mediated 'red man syndrome'. Fever, rash, neutropenia, and other manifestations have also been variably associated with a vancomycin hypersensitivity reaction that is likely immunologically mediated. Here we report a 45-year old man who developed diffuse oral aphthous-like ulcers as the most prominent manifestation of vancomycin hypersensitivity reaction. We identified only two...
Open Access DOI:10.23937/2469-5750/1510003
Luke Maxfield and David A. Gaston
Article Type: Case Report | First Published: May 30, 2015
Exogenous ochronosis is a rare condition of paradoxical skin darkening seen with use of the skin lightening agent hydroquinone. Incidence has been highest in patients with darker skin types, prolonged use, and higher concentration treatment, but has been reported with low dose (2%) as well. Here we present a rare case of exogenous ochronosis, with resultant skin and nail hyperpigmentation, occurring in a Caucasian female using 3% hydroquinone cream over an eighteen-month period....
Open Access DOI:10.23937/2469-5750/1510002
Azar Hadi Maluki and Haider Abdulrasool Al-Sabak
Article Type: Original Article | First Published: May 14, 2015
This comparative split face clinical study was carried out in Laser Research Unit, College of Medicine, University of Kufa, Iraq; for the period from October 2012 to December 2013. Each patient's face was divided into two halves, each half was treated with one of the two laser devices used in this study; Fractional Erbium: Glass 1540nm and Nd: YAG Q-Switched 1064nm lasers....
Open Access DOI:10.23937/2469-5750/1510001
Umbert-Millet Pablo, Sola-Ortigosa Joaquim, Campos Begona and Bassas-Vila Julio
Article Type: Original Article | First Published: March 16, 2015
Background: Dermoscopy, diagnostic cytology, confocal microscopy are used to improve diagnostic accuracy. Frozen section techniques have been used to control margins but not for diagnosis. Objectives: We used a new frozen section technique called immediate cutaneous diagnosis for nonmelanoma skin cancer, assessing its feasibility and accuracy in obtaining a result within 15 minutes and recording limitations....
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